Evidence map›Paper›PMID 42032008›Full record

Articlenpj biomedical innovations2025

Multifunctional robotic micromanipulation system for automated cardiovascular disease therapy using zebrafish.

Zhongyi Guo, Nana Ai, Xianli Wang, Cheong-Meng Chong, Wei Ge, Qingsong Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj biomedical innovations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhongyi GuoDepartment of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Macau, China.
Nana AiDepartment of Biomedical Sciences and Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Macau, China.
Xianli WangDepartment of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Macau, China.
Cheong-Meng ChongState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
Wei GeDepartment of Biomedical Sciences and Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Macau, China. weige@um.edu.mo.
Qingsong XuDepartment of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Macau, China. qsxu@um.edu.mo.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515011178Fundo para o Desenvolvimento das Ciências e da Tecnologia 0086/2022/AFJFundo para o Desenvolvimento das Ciências e da Tecnologia 0102/2022/A2National Natural Science Foundation of China 52175556Research Services and Knowledge Transfer Office, University of Macau MYRG-CRG2022-00004-FST-ICIResearch Services and Knowledge Transfer Office, University of Macau MYRG-GRG2023-00144-FHS-UMDF
6 · The paper itself

Abstract

This paper proposes a multifunctional robotic micromanipulation system for automated microinjection and cardiac rhythm monitoring of zebrafish larvae. An indirect localization method for zebrafish larval hearts is introduced, and a visual algorithm based on modulo operation is devised to locate the zebrafish atrium and ventricle accurately. For the first time, a batch of zebrafish larval yolk is injected and their cardiac rhythm is monitored during the entire developmental stages of zebrafish larvae, which is enabled by the developed robotic system. The system has been applied to investigate the effects of different concentrations of Tricaine (MS222) on zebrafish larvae and the influences of Aspirin on cardiovascular activities. It decreases the dosage by over 60% for heart disease treatment compared to traditional water-based administration. Experimental results verified the functionality and accuracy of the reported system, suggesting that the robotic micromanipulation system can effectively liberate human labor from complex and repetitive tasks.

Identifiers

PMID42032008
PMCPMC13055092

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.