ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026
Mortality in patients over 65 with proximal humerus fractures: a systematic review of 414,379 shoulders with meta-analysis.
Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeProximal humerus fractures (PHFs) often lead to significant morbidity and are associated with an increased risk of mortality. The aim of this study was to assess the mortality rate in patients ≥ 65 years with PHFs. Mortality risk was assessed for 30-day/in-hospital, 1-year, and 5-year follow-up, and was compared based on treatment type.
methodsA systematic review and meta-analysis was performed in accordance with PRISMA guidelines. Studies were included if they reported mortality rates at 30-day/in-hospital, 1-year, or 5-year in patients ≥ 65 years with PHFs. Data were analysed using a random-effects model to account for anticipated heterogeneity. Subgroup analysis was performed by treatment type (operative vs non-operative).
resultsSeventeen studies including 414,379 shoulders (82% female) with a mean age of 78.8 ± 2.5 reported 1-year mortality. Meta-analysis yielded a pooled 1-year mortality rate of 10% (95% CI 8.97-11.20%). Pooled 30-day/in-hospital mortality was 1.74% (95% CI 1.39-2.10%), and 5-year mortality was 36.10% (95% CI 34.50-37.70%). Mortality was lower in the operative group (7.92%, 95% CI 6.98-8.86%) compared to non-operative group (10.80%, 95% CI 9.44-12.17%), with a difference of - 2.89% (95% CI - 4.54 to - 1.23%). However, this finding should be interpreted with caution due to likely confounding by indication inherent in observational studies.
conclusionFor patients ≥ 65 years, PHFs are associated with high rates of mortality in the short-to-medium-term: 10.1% at 1 year and 36.1% at 5-year follow-up. These high mortality rates in patients ≥ 65 years support that PHFs are fragility fractures, and these patients could benefit from comprehensive geriatric assessment in defined orthogeriatric pathways.
Indexed as
Identifiers
42032046What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.