Evidence map›Paper›PMID 42032661›Full record

ArticleCost effectiveness and resource allocation : C/E2026

Cost-effectiveness of a brief cognitive-behavioral outpatient rehabilitation program for patients with post-COVID-19 condition within a pragmatic randomized controlled trial.

Tom Farmen Nerli, Joel Selvakumar, Ingar Heier, Tone Langjordet Johnsen, Vegard Bruun Bratholm Wyller, Torbjørn Wisløff

Registry-linked trialAbstract read
In one paragraph

Article in Cost effectiveness and resource allocation : C/E, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05196451 (Short-time Behavioural Intervention in Post-Covid Syndrome), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05196451 nacompletednot on this map

Short-time Behavioural Intervention in Post-Covid Syndrome (SIPCOV): A Pragmatic Randomised Controlled Trial

TypeinterventionalSponsorUniversity Hospital, AkershusRan2022 to 2024Enrolled314ConditionsCOVID-19ArmsRehabilitation based on CBT principles
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tom Farmen NerliDept. of Paediatrics and Adolescent Health, Akershus University Hospital, PO Box 1000, Lørenskog, N-1478, Norway. tomfar@siv.no.
Joel SelvakumarDept. of Paediatrics and Adolescent Health, Akershus University Hospital, PO Box 1000, Lørenskog, N-1478, Norway.
Ingar HeierDivision of Physical Medicine and Rehabilitation, Vestfold Hospital Trust, Tønsberg, Norway.
Tone Langjordet JohnsenDepartment of Health, Social and Welfare Studies, University of South-Eastern Norway, Horten, Norway.
Vegard Bruun Bratholm WyllerDept. of Paediatrics and Adolescent Health, Akershus University Hospital, PO Box 1000, Lørenskog, N-1478, Norway.
Torbjørn WisløffInstitute of Clinical Medicine, University of Oslo, PO Box 1171, Blindern, Oslo, N-0318, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-COVID-19 condition is an ongoing public health concern, and the lack of established treatments increases health care utilization. Recent evidence suggests that cognitive and behavioral approaches reduce symptoms and improve functional capabilities. This study reports the cost-effectiveness of a brief outpatient cognitive-behavioral rehabilitation program compared to care as usual in non-hospitalized patients with post-COVID-19 condition.

methodsAn economic evaluation based on a randomized clinical trial was conducted from a health care sector perspective. Health care utilization was charted using a self-developed questionnaire administered immediately after the intervention as well as 12 months after inclusion. Health-related quality of life was measured using the EQ-5D-5L inventory at inclusion and follow-ups and valued using the Norwegian tariff. We used multiple imputation with chained equations to impute missing data. To illustrate analysis of uncertainty, bootstrapping was performed. To account for correlation between costs and quality-adjusted life years (QALYs), we conducted seemingly unrelated regression. Costs and QALYs were summarized over the entire 12-month follow-up period.

resultsOver 12 months, analysis yielded an incremental QALY gain of 0.056 (95% CI: 0.024 to 0.077) and an overall cost reduction of NOK − 20,682 (95% CI: -47230 to -1614) per patient receiving the brief outpatient rehabilitation program compared to care as usual. A total of 100% of simulations indicated that the intervention was cost-effective.

conclusionA brief outpatient rehabilitation program based on a cognitive and behavioral approach was cost-effective compared to care as usual in non-hospitalized patients with post-COVID-19 condition. Further investigations of comparable clinical trials within other health care systems are warranted.

trial registrationClinicalTrials.gov Identifier: NCT05196451, 19th January 2022.

Indexed as

cognitive behavioral therapycost-effectiveness analysisoutpatientpost-COVID-19 conditionQALYsRandomized clinical trialrehabilitation

Identifiers

PMID42032661
PMCPMC13244644

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.