ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[Prognostic nutritional index and risk of incident hyperuricemia: A retrospective cohort study].
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThe prognostic nutritional index (PNI) is a composite indicator reflecting nutritional and immune status; however, its association with incident hyperuricemia (HUA) remains unclear. This large-scale retrospective cohort study aims to investigate the relationship between PNI and the risk of developing HUA, providing evidence for early screening and nutritional intervention strategies.
methodsA total of 22 551 individuals who underwent baseline health examinations in 2012 were included. Participants were categorized into quartiles according to PNI levels (Q1, <52.4; Q2, 52.4-<55.1; Q3, 55.1-<57.9; Q4, ≥57.9). Cox proportional hazards models were used to evaluate the association between PNI and incident HUA, with progressive adjustment for age, sex, body mass index (BMI), hypertension, diabetes, dyslipidemia, and renal function. Using Q1 as the reference group, hazard ratios (
resultsThe numbers of participants in Q1-Q4 were 5 468, 5 658, 5 680, and 5 745, respectively. During a median follow-up of 10.5 years, 5 247 incident HUA cases were identified. In the fully adjusted model, participants in Q4 had an 18.4% higher risk of HUA compared with Q1 [
conclusionsElevated PNI (≥57.9) is an independent risk factor for incident HUA in a general health examination population, and this association is significantly modified by hypertension status. As a readily available composite marker, PNI may facilitate early identification of individuals at high risk for HUA and support personalized screening and intervention strategies.
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