ArticleClinical transplantation2026
Performance of Predefined Viability Criteria During Prolonged End-Ischemic Normothermic Perfusion of Brain-Dead Donor Liver Grafts.
Article in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNormothermic machine perfusion (NMP) maintains physiological metabolism ex situ and enables functional assessment of liver grafts. However, the clinical performance of predefined viability criteria in liver transplantation from brain-death donors (DBD) remains uncertain.
methodsThis single-center study, an ancillary of the OVERNIGHT NMP program (Rennes University Hospital, 2021-2023), evaluated predefined viability thresholds applied during prolonged end-ischemic NMP. All adult DBD grafts retrieved between 16:00 and 00:00 underwent NMP until scheduled transplantation the following morning. Grafts meeting predefined viability criteria were transplanted. Outcomes were compared with 1:3 propensity-matched controls preserved by static cold storage (SCS) in exploratory, hypothesis-generating analyses. The primary endpoint was early allograft dysfunction (EAD); a modified definition (mEAD, excluding transaminase criteria) was used as a sensitivity analysis. Secondary endpoints included primary non-function (PNF), biliary and vascular complications, and death-censored graft survival.
resultsAmong 382 liver transplants, 18 NMP and 54 matched SCS recipients were analyzed. All 18 NMP grafts fulfilling predefined thresholds were transplanted, while two non-viable grafts were discarded. No PNF occurred. EAD and mEAD rates were comparable between NMP and SCS (44.4% vs. 26.0%, p = 0.204; 17% vs. 24%, p = 0.550). Biliary complications, requiring endoscopic or surgical intervention, were similar (43.8% vs. 36.6%, p = 0.684). Death-censored graft survival at 24 months did not differ (88.5% vs. 96.0%, p = 0.584).
conclusionsPredefined viability criteria applied during NMP allowed safe identification of transplantable DBD grafts. However, functional assessment based solely on hepatocellular markers was insufficient to anticipate biliary complications, underscoring the need for integrative viability algorithms incorporating cholangiocellular or molecular indicators.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.