Evidence map›Paper›PMID 42033463›Full record

ArticlePlant cell reports2026

A conserved germanicol synthase lineage and a single-residue switch controlling triterpene scaffold divergence in Panax.

Xue Wang, Jingyang Ding, Shiyan Yuan, Haiyan Li, Yongkang Zhang, Guisheng Xiang, Xianbin Deng, Zihan Yang, Shengchao Yang, Xiaobo Li and 1 more

Abstract read
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Article in Plant cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xue Wang *College of Agronomy and Biotechnology, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China.
Jingyang Ding *College of Agronomy and Biotechnology, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China.
Shiyan YuanCollege of Agronomy and Biotechnology, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China.
Haiyan LiCollege of Agronomy and Biotechnology, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China.
Yongkang ZhangCollege of Agronomy and Biotechnology, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China.
Guisheng XiangCollege of Agronomy and Biotechnology, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China.
Xianbin DengYunnan Province Key Laboratory of Cross-Border Chinese Herbal Materials, Honghe University, Mengzi, Yunnan, China.
Zihan YangCollege of Agronomy and Biotechnology, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China.
Shengchao YangCollege of Agronomy and Biotechnology, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China. shengchaoyang@163.com.
Xiaobo LiCollege of Agronomy and Biotechnology, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China. lixiaobo-2007@163.com.
Guanghui ZhangCollege of Agronomy and Biotechnology, National and Local Joint Engineering Research Center on Germplasm Innovation and Utilization of Chinese Medicinal Materials in Southwest China, Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China. zgh73107310@163.com.

Funding

National Natural Science Foundation of China 32560240the Open Research Project of Yunnan Characteristic Plant Extraction Laboratory YKKF2024020the Yunnan International Joint Laboratory of Rare Panax Resources between China and Vietnam 202503AP140007
6 · The paper itself

Abstract

key messageA conserved germanicol synthase (GNS) lineage exists in Panax; a single methionine-to-asparagine switch at residue 728 controls triterpene scaffold divergence from β-amyrin to germanicol. Triterpenoid scaffold diversification in Panax is governed by oxidosqualene cyclases (OSCs); however, it remains unclear whether this genus has the ability to produce noncanonical pentacyclic skeletons. In this study, we functionally characterized a previously unrecognized germanicol synthase (PvOSC9) alongside its paralog, β-amyrin synthase (βAS), known as PvOSC8, from Panax vietnamensis var. fuscidiscus. Structural comparisons reveal a single residue 728 (Asn ↔ Met) that alters carbocation folding trajectories, thereby establishing a minimal molecular switch for scaffold identity. Notably, PvOSC9 is enriched in flowers and responds to jasmonate, suggesting a possible context-dependent role of PvOSC9 in floral tissues. Collectively, these findings broaden the triterpene scaffold repertoire in Panax and offer a mechanistically grounded framework for programmable triterpenoid biosynthesis.

Indexed as

Intramolecular TransferasesPanaxPlant ProteinsTriterpenesAmino Acid SequenceCyclopentanesFlowersGene Expression Regulation, PlantOleanolic AcidOxylipinsPhylogeny2,3-oxidosqualene-beta-amyrin-cyclaseCyclopentanesIntramolecular Transferasesjasmonic acidOleanolic AcidOxylipinsPlant ProteinsTriterpenesGermanicol synthaseOxidosqualene cyclasePanax vietnamensis var. fuscidiscusSite-directed mutagenesisTriterpene scaffold

Identifiers

PMID42033463

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.