Evidence map›Paper›PMID 42033878›Full record

ArticleJournal of psychiatric research2026

Neighborhood disadvantage and accelerated epigenetic aging in the early aftermath of trauma: The moderating role of individual psychological resources.

E Kate Webb, Anthony S Zannas, Sarah D Linnstaedt, Stacey L House, Francesca L Beaudoin, Xinming An, Jennifer S Stevens, Thomas C Neylan, Gari D Clifford, Tanja Jovanovic and 25 more

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Article in Journal of psychiatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

E Kate WebbDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA. Electronic address: kate.webb@duke.edu.
Anthony S ZannasDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Carolina Stress Initiative, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Sarah D LinnstaedtInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Francesca L BeaudoinDepartment of Epidemiology, Brown University, Providence, RI, 02930, USA; Department of Emergency Medicine, Brown University, Providence, RI, 02930, USA.
Xinming AnInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Thomas C NeylanDepartment of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, 94143, USA.
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, 30332, USA; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, 48202, USA.
Scott L RauchDepartment of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, 02478, USA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA.
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, MI, 48202, USA.
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.
Christopher W JonesDepartment of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, 08103, USA.
Jose L PascualDepartment of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Mark J SeamonPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Erica HarrisDepartment of Emergency Medicine, Einstein Medical Center, Philadelphia, PA, 19107, USA.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, 48236, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA; Department of Emergency Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Roland C MerchantDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Robert M DomeierDepartment of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, 48197, USA.
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, 01107, USA.
Brian J O'NeilDepartment of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, 48202, USA.
Paulina SergotDepartment of Emergency Medicine, McGovern Medical School at UTHealth, Houston, TX, 77030, USA.
Leon D SanchezDepartment of Emergency Medicine, Harvard Medical School, Boston, MA, 02115, USA; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, 63121, USA.
Steven E HarteDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA; Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, 02115, USA.
Kerry J ResslerDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.
Samuel A McLeanDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Nathaniel G HarnettDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.

Funding

Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Psychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M
Interplay between biological aging and neuropsychiatric phenotypes after traumaR01AG088241 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Anthony S. Zannas · 2025 to 2026
$1.3M
Multimodal characterization of affective visual processing in the early aftermath of traumaK01MH129828 · NIMH · MCLEAN HOSPITAL · PI Nathaniel G Harnett · 2023 to 2026
$719k
The Biological Cost of External and Internal Resilience Factors in Trauma SurvivorsF32MH134443 · NIMH · MCLEAN HOSPITAL · PI WEBB, ELISABETH KATHLEEN · 2023 to 2023
$69k
NIA NIH HHS R01 AG088241NIMH NIH HHS F32 MH134443NIMH NIH HHS K01 MH129828NIMH NIH HHS R01 MH106595NIMH NIH HHS U01 MH110925
6 · The paper itself

Abstract

Socioenvironmental factors may be associated with patterns of biological age and modify individual vulnerability to trauma- and stress-related psychiatric conditions. We examined whether neighborhood socioeconomic disadvantage is associated with accelerated epigenetic aging in the early aftermath of trauma. Next, we tested whether individual psychological resources, previously shown to attenuate stress-related accelerated aging, moderated the association between neighborhood disadvantage and epigenetic aging. Participants provided blood samples approximately 2 weeks post-trauma (N = 203; 64% female) and completed sociodemographic and psychometric assessments, including a measure of individual psychological resources (Connor-Davidson Resilience Scale [CD-RISC]). Epigenetic aging was assessed using the Horvath, Hannum, GrimAge, PhenoAge, and DunedinPACE clocks. Neighborhood disadvantage (national area deprivation index [ADI]) was derived from participants' home addresses. Linear models evaluated the relationship between ADI and epigenetic aging as well as a subsequent CD-RISC x ADI interaction after covarying for chronological age, income, sex, lifetime trauma, lifetime tobacco and alcohol use, PTSD symptoms, and five estimated cell-type proportions. Higher ADI was associated with accelerated aging in GrimAge, PhenoAge, and DunedinPACE models (ps

Indexed as

AgingEpigenesis, GeneticNeighborhood CharacteristicsPsychological TraumaResidence CharacteristicsResilience, PsychologicalStress Disorders, Post-TraumaticAdultFemaleHumansMaleMiddle AgedSocioeconomic Disparities in HealthEpigenetic agingNeighborhood disadvantageResilienceStress

Identifiers

PMID42033878
PMCPMC13351918

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.