ArticleJournal of cancer research and clinical oncology2026
Idiopathic pulmonary fibrosis predicts local recurrence following surgery in patients with non-small cell lung cancer.
Article in Journal of cancer research and clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe prognosis of lung cancer patients with idiopathic pulmonary fibrosis (IPF) is reported to be worse than that of those without IPF. Herein, we investigated the prognosis of non-small cell lung cancer (NSCLC) patients with and without IPF who underwent resection, and established a new postoperative therapeutic strategy for NSCLC patients with IPF.
methodsBetween 2011 and 2020, 437 consecutive patients with pathological stage I NSCLC who underwent complete resection with systematic lymph node dissection were retrospectively analyzed.
resultsOf 437 patients, post-propensity score matching analysis showed the five-year recurrence-free probability was significantly lower for patients with IPF than for those without IPF (32.3% and 76.1%, respectively; p < 0.001). Compared to those without IPF, postoperative lung metastasis was more frequently encountered in patients with IPF. We then hypothesized that the lung microenvironment of IPF facilitates pulmonary tumor recurrence. In an in vivo mouse model of bleomycin (BLM)-induced IPF, the lung microenvironment of IPF promoted lung metastasis of lung cancer cells which was inhibited by the pharmacological treatment of IPF with pirfenidone (PFD).
conclusionThe results of our in vivo model illustrated that the microenvironment of BLM-induced interstitial pneumonia facilitated the development of postoperative lung metastasis.
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