Liver progenitor cells perform wound healing in a scratch assay by concerted bistable circuits.

Marija Lazovska, Kristine Salmina, Dace Pjanova, Pawel Zayakin, Bogdan I Gerashchenko, Jekaterina Erenpreisa

Abstract read

In one paragraph

Article in NPJ systems biology and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Marija LazovskaInstitute of Oncology and Molecular Genetics, Riga Stradins University, Riga, Latvia.

Kristine SalminaLatvian Biomedical Research and Study Centre, Riga, Latvia.

Dace PjanovaLatvian Biomedical Research and Study Centre, Riga, Latvia.

Pawel ZayakinLatvian Biomedical Research and Study Centre, Riga, Latvia.

Bogdan I GerashchenkoR.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.

Jekaterina ErenpreisaLatvian Biomedical Research and Study Centre, Riga, Latvia. katrina@biomed.lu.lv.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver progenitor cells (LPC) exhibit the potential to differentiate into both hepatocytes and cholangiocytes, making them promising candidates for cell therapy in cases of severe liver pathology. However, the mechanisms of LPCs regeneration are unclear. Here, we utilised rat liver stem-like epithelial cells (WB-F344) in a wound-healing assay. The scratched near-confluent monolayer (70% area removed) underwent G1-arrest, transient bi-nucleation at 10-12 h post-injury, the epithelial-mesenchymal transition, and motion of cell fraction into the wounded areas. The transient displacement of the nuclear NANOG with upregulated p16

Indexed as

LiverStem CellsWound HealingAnimalsCell DifferentiationCell ProliferationCyclin-Dependent Kinase Inhibitor p16Epithelial CellsEpithelial-Mesenchymal TransitionHepatocytesNanog Homeobox ProteinRatsCyclin-Dependent Kinase Inhibitor p16Nanog Homeobox Protein

Identifiers

PMID42034900

DOI10.1038/s41540-026-00724-0

PMCPMC13319447

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.