Dehydrocostus lactone attenuates hepatic steatosis by regulating fatty acid oxidation and lipid metabolism: integrated transcriptomic and metabolomic analysis.

Xiaojia Chen, Pengfei Zhang, Haolin Liang, Jiahai Xiao, Weitao Hong, Gengji Chen, Ruhong Chen, Zhizhen Zhang

Abstract read

In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaojia Chen *School of Basic Medical Sciences, Guangdong Medical University, Dongguan, 523808, China.

Pengfei Zhang *Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, China.

Haolin LiangSchool of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.

Jiahai XiaoSchool of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.

Weitao HongSchool of Medical Technology, Guangdong Medical University, Dongguan, 523808, China.

Gengji ChenSchool of Basic Medical Sciences, Guangdong Medical University, Dongguan, 523808, China.

Ruhong ChenClinic of Guangdong Medical University, Dongguan, 523808, China. 1015056081@qq.com.

Zhizhen ZhangSchool of Basic Medical Sciences, Guangdong Medical University, Dongguan, 523808, China. zzzhang@gdmu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation of China 2020A1515010224Guangdong Basic and Applied Basic Research Foundation of China 2024A1515013288

6 · The paper itself

Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) and atherosclerosis (AS) are closely linked cardiometabolic disorders characterized by dysregulated lipid metabolism, inflammation, and insulin resistance. This study investigated the effects of dehydrocostus lactone (DHL) on hepatic lipid metabolism and histopathology in a preclinical mouse model of concurrent MAFLD and AS, and elucidated its underlying molecular mechanisms. Apolipoprotein E-deficient (ApoE

Indexed as

Fatty AcidsFatty LiverLactonesLipid MetabolismNon-alcoholic Fatty Liver DiseaseSesquiterpenesAnimalsCarnitine O-PalmitoyltransferaseDiet, High-FatLiverMaleMetabolomicsMiceMice, Inbred C57BLMice, KnockoutOxidation-ReductionCarnitine O-Palmitoyltransferasedehydrocostus lactoneFatty AcidsLactonesPPAR alphaSesquiterpenesDehydrocostus lactoneHepatic steatosisMetabolomics FABP5/PPAR-α/CPT1-βTranscriptomics

Identifiers

PMID42036469

DOI10.1007/s00210-026-05388-5

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.