Evidence map›Paper›PMID 42036612›Full record

ReviewAdvances in experimental medicine and biology2026

Environmental Transgenerational Epigenetics: Effects on Fertility and Offspring Health.

Sarah De Santos, Michael K Skinner

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sarah De SantosCenter for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA.
Michael K SkinnerCenter for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA. skinner@wsu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of environmentally induced epigenetic transgenerational inheritance on the fertility and health of organisms' offspring are reviewed. Previously, researchers have demonstrated a wide variety of environmental toxicants can promote an increase in disease and pathology in future generations through epigenetic transgenerational inheritance. These epigenetic alterations are transmitted through the germ line to future generations, influencing subsequent generations fertility and health. These epigenetic alterations provide a molecular mechanism for the decrease in fertility rates of subsequent generations and are associated with increases in disease. The increase in disease and pathology that humans are currently experiencing on a global scale appears to in part come from ancestral exposures and epigenetics. Although we may not be able to fix the problem, advancements in assisted reproduction and epigenetic disease biomarker tests to diagnose patients disease susceptibility will allow medical care providers to be more proactive in the preventative medicine treatment to reduce the frequency of disease-related ailments prior to the onset of the pathology.

Indexed as

Environmental ExposureEnvironmental PollutantsEpigenesis, GeneticFertilityGene-Environment InteractionAnimalsDevelopmental Origins of Health and DiseaseDNA MethylationEpigenetic MemoryFemaleGenetic Predisposition to DiseaseHumansMaleEnvironmental PollutantsDNA methylationEpigenetic biomarkerEpigeneticsEpigenetic transgenerational inheritanceEvolutionary biologyGermlineMale infertilityPreventative medicineSpermatogenesis

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.