SynthesisMicrobiologyOpen2026
Kefir: A Potential Gut Microbiota Modulator: A Systematic Review of Human Interventional Studies.
Synthesis in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gut microbiota-mediated biotransformation of dietary bioactive compounds: inter-individual variability, determinants, and implications for personalised nutrition.Frontiers in systems biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kefir is a fermented dairy product containing live and active microbial culture, including lactic acid bacteria and yeast. Preclinical studies and narrative reviews have reported potential modulatory effects of kefir on gut microbiota composition. Despite this, there isn't yet a thorough analysis of human intervention studies that fills this gap of research. Therefore, the aim of this review is to examine the role of kefir consumption on gut microbiota composition in humans. Comprehensive research was conducted using three major databases including Web of Science, PubMed, and Scopus. The risk of bias was assessed using Cochrane risk-of-bias tool and Risk of bias of non-randomized trials. The search resulted in 2743 studies, of which eight studies met our eligibility criteria. Overall, kefir resulted in minor changes in phyla and class levels. On the other hand, the Bifidobacterium genus increased in 3 out of 4 studies. Kefir-specific bacterial species and strains were found in participants fecal samples suggesting colonization properties. Kefir consumption was associated with modest and heterogenous changes in gut microbiota composition. Proposed mechanisms include transient persistent of kefir-associated taxa and modulation of the intestinal environment, although direct functional evidence in humans remains limited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.