Evidence map›Paper›PMID 42037015›Full record

ArticleMovement disorders clinical practice2026

Cardiac MIBG Scintigraphy in Neurodegenerative Parkinsonism: Limitations in Clinical Practice.

Frank Jagusch, Elena Redl, Christoph Theyer, Atbin Djamshidian, Alessandra Fanciulli, Werner Poewe, Philipp Mahlknecht, Beatrice Heim, Klaus Seppi, Florian Krismer

Abstract read
In one paragraph

Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Frank JaguschDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.ORCID https://orcid.org/0009-0005-3996-0871
Elena RedlDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Christoph TheyerDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.ORCID https://orcid.org/0009-0001-3499-6163
Atbin DjamshidianDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Alessandra FanciulliDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.ORCID https://orcid.org/0000-0002-2854-4179
Werner PoeweDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Philipp MahlknechtDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.ORCID https://orcid.org/0000-0003-0671-0516
Beatrice HeimDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.ORCID https://orcid.org/0000-0002-6749-3044
Klaus SeppiDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Florian KrismerDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.ORCID https://orcid.org/0000-0002-4493-5073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReduced cardiac uptake on

objectivesThis study investigated factors limiting the clinical applicability of MIBG scintigraphy in everyday clinical practice.

methodsPatient records (2021-2022) were retrospectively reviewed, independent of whether MIBG scintigraphy was performed, for comorbidities and concomitant medication confounding its interpretation.

resultsSix hundred ninety five patients (640 Parkinson's disease, 22 multiple system atrophy, 33 progressive supranuclear palsy) were included. Factors potentially influencing cardiac MIBG binding were present in 55.3% with 18.1% exhibiting multiple factors. Medications with known drug-tracer interactions were found in 46.9% and comorbidities associated with reduced cardiac MIBG uptake in 20.9%.

conclusionsThe clinical utility of MIBG scintigraphy is frequently restricted by medications and comorbidities highlighting the need of careful planning in clinical practice.

Indexed as

123I‐meta‐iodobenzylguanidine (123I‐MIBG) myocardial scintigraphyclinical applicationsmultiple system atrophyParkinson's diseaseprogressive supranuclear palsy

Identifiers

PMID42037015
PMCPMC13338996

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.