Evidence map›Paper›PMID 42037246›Full record

ArticleAnnals of medicine2026

Mutations in CHIP-associated genes at myeloid neoplasm diagnosis and risk of cardiovascular/cerebrovascular events.

Yao Wang, Dewan Zhao, Yulong Chen, He Xu, Guirong Song, Xiuli Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yao WangDepartment of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Dewan ZhaoDepartment of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.ORCID 0000-0002-2292-8892
Yulong ChenSchool of Public Health, Dalian Medical University, Dalian, China.
He XuDepartment of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Guirong SongSchool of Public Health, Dalian Medical University, Dalian, China.
Xiuli SunDepartment of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClonal hematopoiesis of indeterminate potential (CHIP)-associated somatic mutations are associated with increased cardiovascular and cerebrovascular risk in the general population; whether mutations detected at myeloid neoplasm (MN) diagnosis predict incident cardiovascular and cerebrovascular events (CCVEs) is unclear.

methodsWe retrospectively studied 203 adults with newly diagnosed myelodysplastic neoplasms, myelodysplastic/myeloproliferative neoplasms, or acute myeloid leukemia unfit for intensive chemotherapy (2016-2023) who underwent pretreatment next-generation sequencing. Cause-specific hazard models adjusted for cardiovascular risk factors assessed associations between CHIP-associated gene mutations and incident CCVEs, including age-stratified and age-by-mutation interaction analyses.

resultsMedian age was 68 years (IQR, 61-75); 127 (62.6%) were male; 141 (69.5%) carried ≥1 CHIP-associated gene mutation, most commonly

conclusionsCHIP-associated gene mutations at MN diagnosis were not independently associated with incident CCVEs. Older mutation-positive patients had higher observed CCVE risk, predominantly heart failure, with limited precision. These exploratory findings warrant prospective multicenter validation.

Indexed as

Cardiovascular DiseasesCerebrovascular DisordersClonal HematopoiesisLeukemia, Myeloid, AcuteMyelodysplastic SyndromesAgedDNA-Binding ProteinsDNA Methyltransferase 3AFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedMutationRepressor ProteinsRetrospective StudiesASXL1 protein, humanDNA-Binding ProteinsDNA Methyltransferase 3ARepressor Proteinscardiovascular eventscerebrovascular eventsclonal hematopoiesisMyeloid neoplasmssomatic mutations

Identifiers

PMID42037246
PMCPMC13123072

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.