ArticleTherapeutics and clinical risk management2026
Pregnancy Outcomes Following Medical Therapy versus Levonorgestrel-Releasing Intrauterine System for Atypical Endometrial Hyperplasia.
Article in Therapeutics and clinical risk management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To compare pregnancy outcomes between systemic progestin therapy and levonorgestrel-releasing intrauterine system (LNG-IUS) in patients with atypical endometrial hyperplasia (AEH) desiring fertility preservation. Methods: This single-center retrospective cohort study included AEH patients who underwent fertility-sparing treatment between January 2017 and December 2024. Patients received either systemic progestins (medroxyprogesterone acetate [MPA] 250-600 mg/day, megestrol acetate [MA] 160-320 mg/day, or dydrogesterone 20-40 mg/day) or LNG-IUS. Primary outcomes were clinical pregnancy rate and live birth rate. Secondary outcomes included time to pregnancy (TTP), conception mode, and disease recurrence rate. Propensity score matching (PSM) controlled for confounders including age, body mass index, polycystic ovary syndrome, and infertility duration. Results: Of 186 patients (121 medical therapy, 65 LNG-IUS), 58 per group were analyzed after PSM. Complete remission rates were 77.6% (45/58) versus 84.5% (49/58) (adjusted OR 1.52, 95% CI 0.71-3.26, p=0.28). Among patients achieving complete remission, clinical pregnancy rates were 51.1% (23/45) versus 67.3% (33/49) (adjusted OR 2.14, 95% CI 1.08-4.25, p=0.029). Live birth rates were 37.8% (17/45) versus 55.1% (27/49) (adjusted OR 2.28, 95% CI 1.13-4.62, p=0.022). Median TTP was 8.5 months (IQR 6-14) versus 6.0 months (IQR 4-10) (HR 1.64, 95% CI 1.12-2.41, p=0.011). Per-protocol analysis yielded consistent results. Conclusion: LNG-IUS treatment was associated with significantly higher clinical pregnancy rates, live birth rates, and shorter TTP compared to systemic progestin therapy. These findings support LNG-IUS as a preferred fertility-sparing option for AEH patients, particularly when expedited conception is desired. Results should be interpreted considering the retrospective design, heterogeneous dosing, and potential residual confounding.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.