ArticleFrontiers in dental medicine2026
Calprotectin and aMMP-8 as biomarkers in gingival crevicular fluid in geriatric inpatients.
Article in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Dual-Biomarker Oral-Rinse Testing for aMMP-8 and Calprotectin: A Potential Adjunctive Tool for Risk Stratification and Interdisciplinary Referral in Periodontitis and Type 2 Diabetes.Bioengineering (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
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Abstract
Background: Accurate detection of periodontal inflammation and tissue degradation remains challenging in frail, hospitalized older adults with high periodontitis prevalences, where conventional diagnostics are often not feasible. Biochemical biomarkers such as Calprotectin (CP) and Active Matrix Metalloproteinase-8 (aMMP-8) in Gingival Crevicular Fluid (GCF) may offer low-barrier, bedside-compatible diagnostic alternatives for the future. While aMMP-8 is already well-studied and rather reflects collagen degradation, CP is supposed to indicate neutrophil-driven inflammation. Methods: In this cross-sectional study of 30 neurogeriatric inpatients (mean age 79 ± 6 years) with minimal systemic inflammation (CR Results: CP and aMMP-8 showed a strong correlation (rs = .521), suggesting complementary diagnostic value. CP correlated moderately with BoP (rs = .365), mean PPD (rs = .455) and mean PPD at the sampling sites (rs = .478). aMMP-8 correlated moderately with BoP (rs = .329) and mean PDD (rs = .309). Both biomarkers were not associated with systemic variables. ANOVA revealed an effect of BoP on CP levels ( Conclusion: Both biomarkers demonstrate a feasibility assessment for geriatric inpatients. In this population, CP reflects localized periodontal processes and inflammation. CP may in the future be particularly suited for inflammatory screening in care-dependent older adults. These findings contribute initial reference data and underscore the need for larger studies to validate biomarker-based diagnostics in broader geriatric populations.
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