Evidence map›Paper›PMID 42038686›Full record

ArticleHeart rhythm O22026

Obesity promotes atrial fat deposition independent of myocardial infarction in Göttingen minipigs.

Johs Dannesboe, Caroline Eggert Eggertsen, Karina Poulsdóttir Debes, Mette Flethøj, Lisbeth Høier Olsen, Jacob Eifer Møller, Jeppe Egedal Kirchhoff, Torkel Falk, Nienke Anna Maria van Rooij, Trine Pagh Ludvigsen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Johs DannesboeDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Caroline Eggert EggertsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Karina Poulsdóttir DebesDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Mette FlethøjResearch and Early Development, Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.
Lisbeth Høier OlsenDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Jacob Eifer MøllerDepartment of Cardiology, Copenhagen University Hospital, Denmark, University of Southern Denmark, Odense, Denmark.
Jeppe Egedal KirchhoffResearch and Early Development, Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.
Torkel FalkDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Nienke Anna Maria van RooijDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Trine Pagh LudvigsenResearch and Early Development, Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.
Thomas JespersenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Arnela SaljicDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atrial fibrillation often follows myocardial infarction (MI) and is associated with increased risks of adverse cardiovascular outcomes. Obesity is a potent risk factor for both MI and atrial fibrillation. Objective: This study aimed to understand whether MI and obesity have a synergistic impact on atrial remodeling. Methods: Lean (sham n = 3; MI n = 12) and obese (sham n = 3; MI n = 9) Göttingen minipigs (MI group) underwent a 120-minute balloon occlusion of the left anterior descending coronary artery. After 8 weeks, myocardial tissue was collected from 4 distinct left and right atrial sites for histologic analysis. Results: Obese animals have a significantly higher amount of atrial adipose tissue than lean animals at all 4 sites (right atrium [RA] Conclusion: Obesity is the primary driver of atrial adipose tissue remodeling both in and around the atria. MI had no effect on atrial remodeling at any site in either lean or obese animals.

Indexed as

AtriaHyperplasiaHypertrophyIntramyocardial adipose tissueLipomatous metaplasiaMyocardial infarctionObesity

Identifiers

PMID42038686
PMCPMC13107037

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.