ReviewFrontiers in cell and developmental biology2026
Hair cell loss - cause or consequence of hearing loss?
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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Abstract
Hair cell loss is a major hallmark of hearing loss. Historically, hair cell loss has been considered the major cause of hearing loss. Typically, synapses between hair cells and auditory nerve fibers and stereocilia are lost even before hair cells. Loss of these structures is often irreversible leading to permanent hearing loss. The earlier we can intervene in the course of hearing loss, the better we can maintain hearing function. Therefore, it is of importance to precisely understand the underlying causes and sequence of events leading to hearing loss. Notably, hearing loss precedes hair cell loss in many cases. Upon hearing loss, hair cells are present but exhibit morphological and functional defects. Thus, hair cell loss could merely be a secondary consequence of the loss of function of these sensory cells. Here, we review the literature highlighting that hair cell loss is often secondary to hearing loss. We suggest that hair cell loss is often rather the consequence than the cause of hearing loss.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.