Evidence map›Paper›PMID 42039277›Full record

ArticleActa pharmaceutica Sinica. B2026

Aberrant astroglial Kir4.1 activation in the anterior cingulate cortex disrupts neuronal excitability and social behavior.

Zhengmao Li, Yixuan Zhang, Yan Chen, Ying Zhang, Yunlong Pan, Kerui Wang, Chen Li, Xiangyu Zhao, Weikang Hu, Yifan Luo and 8 more

Abstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zhengmao LiDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China.
Yixuan ZhangMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Yan ChenDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China.
Ying ZhangMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Yunlong PanDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China.
Kerui WangDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China.
Chen LiMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Xiangyu ZhaoMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Weikang HuDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China.
Yifan LuoMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Jiawen ChengDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China.
Hongzhen ZhangMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Kohji FukunagaDepartment of CNS Drug Innovation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Yankai XiaKey Laboratory of Modern Toxicology of Ministry of Education, Nanjing 211166, China.
Jiandong JiangMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Xiuxiu LiuMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Feng HanMedical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Yingmei LuDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenatal herbicide exposure is increasingly linked to neurodevelopmental disorders, yet effective pharmacological interventions remain lacking due to unclear pathogenic mechanisms. Here, we demonstrate that prenatal exposure to glufosinate ammonium (GLA), a widely used herbicide, triggers autism-like behaviors, including social deficits and repetitive grooming, in offspring mice. Whole-brain c-Fos mapping,

Indexed as

Anterior cingulate cortexAstrocyteAutism spectrum disorderDesipramineGlufosiante ammoniumInwardly rectifying potassium channel 4.1OffspringPyramidal neurons

Identifiers

PMID42039277
PMCPMC13104685

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.