ArticleOphthalmology science2026
Maternal Risk Factors for Retinopathy of Prematurity in Korea: A Nationwide Population-Based Study.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To investigate the association between maternal health conditions and the risk of retinopathy of prematurity (ROP) in preterm infants using nationwide population-based data. Design: A retrospective cohort study. Participants: A total of 88 111 live preterm births in Korea between January 1, 2014, and December 31, 2017, identified from linked National Health Insurance Service and National Health Screening Program for Infants and Children databases. Methods: Multivariable logistic regression models were used to estimate adjusted odds ratios (aORs) for maternal risk factors associated with ROP and treatment-requiring ROP. Main Outcome Measures: Incidence of any ROP and treatment-requiring ROP. Results: Of 88 111 preterm infants, 17 181 (19.5%) developed ROP, and 340 (2.0% of ROP cases) required treatment. Maternal diabetes mellitus (aOR, 1.142; Conclusions: Multiple maternal conditions were associated with increased risk of any ROP in preterm infants. Among infants with ROP, ovarian dysfunction independently predicted progression to treatment-requiring disease, whereas preeclampsia and gestational hypertension were associated with reduced risk of severe ROP. Recognition of these maternal risk factors may support prenatal counseling, neonatal risk stratification, and targeted ROP screening. Financial Disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article.
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