How Functional Variants Reconfigure the Rac2 Conformational Landscape.

Nurit Haspel, Hyunbum Jang, Ruth Nussinov

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In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nurit HaspelDepartment of Computer Science, University of Massachusetts Boston, Boston, Massachusetts 02125, U.S.A.ORCID 0000-0003-4810-379X

Hyunbum JangBiophysics and Computational Biology Section, Frederick National Laboratory for Cancer Research in the Cancer Innovation Laboratory, National Cancer Institute, Frederick, MD 21702, U.S.A.ORCID 0000-0001-9402-4051

Ruth NussinovBiophysics and Computational Biology Section, Frederick National Laboratory for Cancer Research in the Cancer Innovation Laboratory, National Cancer Institute, Frederick, MD 21702, U.S.A.ORCID 0000-0002-8115-6415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rac2, a member of the Rho family of small GTPases, is a fundamental regulator of essential cellular processes. Pathogenic substitutions near and within the Switch II region, specifically D57N and E62K, have been implicated in oncogenesis and immunodeficiency. Despite their proximity, D57N is characterized as a loss-of-function mutation, while E62K is a constitutively active, gain-of-function mutation. In this study, we addressed several critical questions: (i) the structural basis of their altered cellular functions, (ii) how these variants rearrange the conformational ensemble, and (iii) the subsequent impact on cellular signaling networks. Using molecular dynamics (MD) simulations, we characterized the conformational dynamics of these Rac2 variants in GDP- and GTP-bound states. Our results demonstrate that Rac2

Indexed as

cancer progressioninsert regionKRasmolecular dynamicsRho familysmall GTPase

Identifiers

PMID42039397

DOI10.64898/2026.04.17.719286

PMCPMC13104822

What Socratic holds

Textmetadata

LicenceCC BY-NC

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.