Evidence map›Paper›PMID 42039664›Full record

ArticlebioRxiv : the preprint server for biology2026

Humanized Klotho haplotypes cause widespread transcriptomic changes in mouse brain.

Anna L Tyler, Dylan Garceau, Kevin P Kotredes, Annat Haber, Catrina Spruce, Ravi S Pandey, Christoph Preuss, Michael Sasner, Gregory W Carter

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna L TylerThe Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.ORCID 0000-0001-8371-2377
Dylan GarceauThe Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
Kevin P KotredesThe Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
Annat HaberThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Catrina SpruceThe Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
Ravi S PandeyThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Christoph PreussThe Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
Michael SasnerThe Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
Gregory W CarterThe Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.ORCID 0000-0002-2834-8186

Funding

The IU/JAX Alzheimer's Disease Precision Models Center: Rat F344U54AG054345 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Paul Richard Territo · 2016 to 2026
$95.6M
Modeling the Genetic Interaction Between Klotho and APOE Alleles in Alzheimer's DiseaseRF1AG075701 · NIA · JACKSON LABORATORY · PI CARTER, GREGORY W, SASNER, MICHAEL · 2022 to 2025
$3.9M
NIA NIH HHS RF1 AG075701NIA NIH HHS U54 AG054345
6 · The paper itself

Abstract

Klotho

Identifiers

PMID42039664
PMCPMC13105077

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.