ArticlePulmonary circulation2026
R213G-Mediated Redistribution of EC-SOD Protects Against Sugen-Hypoxia Pulmonary Hypertension in Mice.
Daniel Colon Hidalgo, Caitlin V Lewis, Thi-Tina N Nguyen, Janelle N Posey, Samuel D Burciaga, Nathan Dee, Christina Sul, Julie Harral, David Irwin, Cassidy Delaney and 1 more
Abstract read
In one paragraphArticle in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Caitlin V LewisDepartments of Pediatrics and Medicine, Cardiovascular Pulmonary Research Group University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Thi-Tina N NguyenDepartments of Pediatrics and Medicine, Cardiovascular Pulmonary Research Group University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Samuel D BurciagaDepartments of Pediatrics and Medicine, Cardiovascular Pulmonary Research Group University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Nathan DeeDepartments of Pediatrics and Medicine, Cardiovascular Pulmonary Research Group University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Christina SulDepartments of Pediatrics and Medicine, Cardiovascular Pulmonary Research Group University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Julie HarralDepartments of Pediatrics and Medicine, Cardiovascular Pulmonary Research Group University of Colorado Anschutz Medical Campus Aurora Colorado USA.
David IrwinDepartments of Pediatrics and Medicine, Cardiovascular Pulmonary Research Group University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Cassidy DelaneyDepartments of Pediatrics and Medicine, Cardiovascular Pulmonary Research Group University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Eva S NozikDepartments of Pediatrics and Medicine, Cardiovascular Pulmonary Research Group University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Funding
Pediatric Critical Care Scientist Development ProgramK12HD047349 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HEATHER T. KEENAN, Kevin M Watt · 2004 to 2026
$17.0MRole of Complement-Driven Pulmonary Vascular Inflammation in PHP01HL152961 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STENMARK, KURT R. · 2020 to 2024
$14.1MSOD3 regulation of redox sensitive signaling in pulmonary vascular diseasesR35HL139726 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI NOZIK, EVA S. · 2018 to 2024
$4.1MExtracellular redox biology links to metabolic and mitochondrial dysfunction in pulmonary hypertensionF32HL167572 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI COLON HIDALGO, DANIEL ANTONIO · 2023 to 2023
$69kNHLBI NIH HHS F32 HL167572NHLBI NIH HHS L70 HL175830NHLBI NIH HHS P01 HL152961NHLBI NIH HHS R35 HL139726NICHD NIH HHS K12 HD047349
6 · The paper itselfAbstract
Pulmonary hypertension (PH) is a progressive and life-threatening disease characterized by pulmonary vascular remodeling that leads to elevated pulmonary artery pressures, and subsequent right ventricular dysfunction. Despite advances in understanding PH pathogenesis, treatment options remain limited, underscoring the need to define novel mechanisms that contribute to disease progression. Inflammation and oxidative stress are recognized drivers of pulmonary vascular injury, with extracellular superoxide dismutase (EC-SOD or
Indexed as
extracellular superoxide dismutase (EC‐SOD)oxidative stressSugen‐hypoxia
Identifiers
PMID42039680
PMCPMC13107549
What Socratic holds
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