ArticleFrontiers in neuroscience2026
Altered volumetric and functional connectivity of the habenula in chronic insomnia disorder.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous findings have demonstrated that habenula (Hb) is a key hub for sleep regulation and emotion processing. However, its role in chronic insomnia disorder (CID) remains understudied. This study aimed to investigate the structural characteristics of the Hb and its functional connectivity (FC) with large-scale brain networks in CID patients. Methods: A total of 42 CID patients and 31 age-, gender-, and education-matched healthy controls (HC) completed clinical questionnaires, structural magnetic resonance imaging (sMRI) and resting-state fMRI (rs-fMRI). Results: No significant group differences were observed in the relative volumes or the laterality index between CID patients and HC. However, voxel-wise FC analysis showed increased FC between the left Hb and the right inferior frontal gyrus, right middle frontal gyrus, and left angular gyrus in CID patients, alongside decreased FC between the left Hb and left inferior frontal gyrus, left precentral gyrus, and right caudate nucleus. The right Hb exhibited decreased FC with the right middle cingulate cortex, supramarginal gyrus and postcentral gyrus. Region-of-interest (ROI)-wise analysis further demonstrated that the left Hb had significantly decreased connectivity with the posterior/anterior somatomotor networks (SM-d, SM-v) and posterior dorsal attention network (DAN- Conclusion: Our findings indicate that CID is characterized by asymmetric FC abnormalities of the bilateral Hb, particularly impaired connectivity between the left Hb and SM and DAN networks, without structural changes. These aberrations provide novel neuroimaging insights into the pathophysiology of CID and highlight the left Hb as a potential target for targeted interventions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.