Evidence map›Paper›PMID 42040895›Full record

ArticleHuman mutation2026

Visualization and Cluster Analysis of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer: Research Trends and Future Directions.

Bo Dong, Bin Zhou, Hong Zhang, Taiqi Wang, Zhaowan Xu, Lin Zhu, Qingyun Li, Ben Niu, Xiaofeng Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bo DongDepartment of Gastro-Pancreatic Surgery, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, China.ORCID https://orcid.org/0000-0003-0342-2084
Bin ZhouLaboratory of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, China, scu.edu.cn.
Hong ZhangSchool of Medicine, Institute of Medical Sciences, Örebro University, Örebro, Sweden, oru.se.
Taiqi WangDepartment of Gastro-Pancreatic Surgery, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, China.
Zhaowan XuDepartment of Gastro-Pancreatic Surgery, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, China.
Lin ZhuDepartment of Gastro-Pancreatic Surgery, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, China.
Qingyun LiDepartment of Gastro-Pancreatic Surgery, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, China.
Ben NiuDepartment of Gastro-Pancreatic Surgery, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, China.
Xiaofeng SunDepartment of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden, liu.se.ORCID https://orcid.org/0000-0003-1253-1901

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Peroxisome proliferator-activated receptors (PPARs) are essential regulators in the development and progression of colorectal cancer (CRC). However, a comprehensive bibliometric analysis of PPAR-related CRC research is lacking. Methods: Publications on PPARs in CRC from 1998 to 2024 were retrieved from the Web of Science Core Collection. VOSviewer, CiteSpace, and the R package bibliometrix were used to analyze publication trends, hotspots, and collaboration networks. Contributions from countries, institutions, authors, and journals were systematically evaluated. Results: A total of 1380 publications were analyzed, with an annual growth rate of 8.33%. The United States led with the highest number of publications (386) and citations (28,461), followed by China and Japan. The University of Texas System was the most productive institution (125 publications). Gonzalez, Frank J. and Peters, Jeffrey M. were the most prolific authors (16 publications each). Conclusion: This study highlights three key research focuses: molecular mechanisms of PPARs in CRC, the link between obesity and CRC, and therapeutic potential. These findings underscore the growing interest in PPAR-mediated metabolic regulation, inflammation, and targeted interventions, offering valuable guidance for future research directions.

Indexed as

Colorectal NeoplasmsPeroxisome Proliferator-Activated ReceptorsBibliometricsCluster AnalysisHumansPeroxisome Proliferator-Activated Receptorsbibliometric analysisCiteSpacecolorectal cancerperoxisome proliferator–activated receptorsVOSviewer

Identifiers

PMID42040895
PMCPMC13107118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.