ArticleBiomimetics (Basel, Switzerland)2026
Laser-Engineered Multilayer Coatings Based on Zinc Oxide and Lovastatin-Functionalized Bioactive Glasses for Corrosion-Resistant and Antimicrobial Stainless Steel Implants.
Article in Biomimetics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Stainless steel (SS) remains widely used in orthopedic implants but is susceptible to corrosion and implant-associated infections in physiological environments. This study aimed to develop a multifunctional multilayer coating combining corrosion resistance, bioactivity, and antimicrobial performance. A ZnO base layer was deposited on 316L SS via pulsed laser deposition, followed by matrix-assisted pulsed laser evaporation of a lovastatin-functionalized bioactive glass (BG57 + LOV) top layer. Two LOV concentrations were initially evaluated, and BG57+0.1LOV was selected based on structural homogeneity, cytocompatibility, and antimicrobial balance. Physicochemical characterization confirmed preservation of chemical integrity and formation of continuous, moderately rough coatings. Electrochemical impedance spectroscopy in simulated body fluid demonstrated progressive improvement in corrosion resistance from bare SS to ZnO-coated and finally to the BG57+0.1LOV/ZnO multilayer, which exhibited the most electropositive corrosion potential and effective suppression of charge-transfer reactions. Biological assays revealed high viability of osteoblasts, fibroblasts, keratinocytes, and macrophages without significant oxidative or nitrosative stress. Antimicrobial testing showed strain-dependent activity, with enhanced efficacy against MRSA and significant reduction in
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