Evidence map›Paper›PMID 42041584›Full record

ArticleCells2026

Extracellular Vesicles Derived from VEGF mRNA-Engineered Mesenchymal Stem Cells Promote Endothelial Cell Survival.

Cuiping Zhang, Peng Huang, Matthew Pak, Jennifer A Korchak, Abba C Zubair

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cuiping ZhangDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-0409-1232
Peng HuangDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-0168-7644
Matthew PakDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32224, USA.
Jennifer A KorchakDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-2679-721X
Abba C ZubairDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-4827-4740

Funding

CSRD VA 1
6 · The paper itself

Abstract

Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) exhibit great therapeutic potential in ischemia-associated conditions and diseases such as myocardial infarction, ischemic stroke, and wound healing. Enhancing the therapeutic efficacy of MSC-EVs could advance their clinical application. Diverse cargos (proteins, mRNA, microRNA, etc.) in MSC-EVs contribute to the therapeutic effects in various diseases. Vascular endothelial growth factor (VEGF) is one of the primary driving molecules in promoting angiogenesis and protecting endothelial cells lining blood vessels from apoptosis. In this study, we explored the feasibility of engineering parent MSCs with

Indexed as

Extracellular VesiclesHuman Umbilical Vein Endothelial CellsMesenchymal Stem CellsRNA, MessengerVascular Endothelial Growth Factor AAnimalsApoptosisCell SurvivalHumansNeovascularization, PhysiologicRNA, MessengerVascular Endothelial Growth Factor Aangiogenesisapoptosisextracellular vesiclesischemic diseasesmesenchymal stem cellVEGF

Identifiers

PMID42041584
PMCPMC13115070

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.