Evidence map›Paper›PMID 42041905›Full record

ArticleBiology2026

Exploratory Single-Nucleus RNA Sequencing Suggests Glial-Specific NPY Upregulation and Cell-Type-Specific Metabolic Alterations in Temporal Lobe Epilepsy.

Chao Jiang, Yan Zhao, Yaning Ding, Shanshan Wu, Le Su, Chenyang Bai, Jian Wang, Chuang Guo, Zhiqiang Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chao JiangKey Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Institute of Neuroscience, Northeastern University, No. 195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Yan ZhaoKey Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Institute of Neuroscience, Northeastern University, No. 195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Yaning DingKey Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Institute of Neuroscience, Northeastern University, No. 195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Shanshan WuKey Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Institute of Neuroscience, Northeastern University, No. 195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Le SuDepartment of Neurosurgery, Chinese People's Liberation Army of General Hospital, 28, Fuxing Road, Haidian District, Beijing 100853, China.
Chenyang BaiKey Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Institute of Neuroscience, Northeastern University, No. 195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Jian WangDepartment of Neurosurgery, Chinese People's Liberation Army of General Hospital, 28, Fuxing Road, Haidian District, Beijing 100853, China.
Chuang GuoKey Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Institute of Neuroscience, Northeastern University, No. 195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Zhiqiang CuiDepartment of Neurosurgery, Chinese People's Liberation Army of General Hospital, 28, Fuxing Road, Haidian District, Beijing 100853, China.

Funding

National Natural Science Foundation of China 32371037National Science and Technology Major Project of the Ministry of Science and Technology of China 2025ZD021504
6 · The paper itself

Abstract

Temporal lobe epilepsy (TLE) is the most common focal epilepsy in adults, but cell-type-specific molecular alterations in the epileptic cortex remain incompletely characterized. We performed single-nucleus RNA sequencing on temporal cortex from three patients with drug-resistant TLE and two non-epileptic controls, retaining 66,932 nuclei. Seven major cell types were annotated. Neuropeptide Y (

Indexed as

metabolic reprogrammingmicroglianeuroinflammationneuropeptide Yoligodendrocytessingle-nucleus RNA sequencingtemporal lobe epilepsy

Identifiers

PMID42041905
PMCPMC13114130

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.