Novel lncRNA Signature (UFC1/PTENP1) as a Molecular Biomarker for the Diagnosis and Prognosis of Hepatocellular Carcinoma in an Egyptian Cohort.

Marwa Hassan, Lobna Abdelsalam, Amal Kotb Behery, Rania Fathy Elnahas

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Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Marwa HassanImmunology Department, Theodor Bilharz Research Institute, Giza 12411, Egypt.ORCID 0000-0001-9751-8129

Lobna AbdelsalamHuman Genetics Department, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.

Amal Kotb BeheryHuman Genetics Department, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.

Rania Fathy ElnahasHuman Genetics Department, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are key regulators of gene expression and play critical roles in cancer-related signaling networks. Dysregulation of antagonistic lncRNAs may contribute to hepatocarcinogenesis and disease progression. This study investigated the clinical significance and predictive value of two biologically antagonistic lncRNAs, UFC1 and PTENP1, as circulating biomarkers for hepatocellular carcinoma (HCC) in an Egyptian cohort. Expression levels of these lncRNAs were quantified in 100 HCC patients and 100 age- and sex-matched healthy controls. UFC1 was significantly upregulated (~2.9-fold), while PTENP1 was markedly downregulated (~4-fold) in HCC patients, with a strong inverse correlation (r = -0.609,

Indexed as

biomarkerdiagnosisEgyptian cohortfibrosishepatocellular carcinomalong non-coding RNA (lncRNA)prognosisPTENP1UFC1

Identifiers

PMID42042020

DOI10.3390/cimb48040360

PMCPMC13114740

What Socratic holds

Textmetadata

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.