Evidence map›Paper›PMID 42043115›Full record

ReviewToxics2026

Not Just a Fish Killer: Multi-Organ Toxicity and Mechanisms of 6PPD-Quinone.

Pinzhi Dong, Meijun Liu, Haiyan Wang, Jin Chen, Xiaorong Xu, Hailong Su, Ming Qin, Junmin Luo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pinzhi DongSpecial Key Laboratory of Gene Detection & Therapy, Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Department of Immunology, School of Basic Medicine, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563000, China.ORCID 0009-0006-5428-6704
Meijun LiuSpecial Key Laboratory of Gene Detection & Therapy, Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Department of Immunology, School of Basic Medicine, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563000, China.
Haiyan WangDepartment of Epidemiology and Health Statistics, Zunyi Medical University, Zunyi 563000, China.
Jin ChenSpecial Key Laboratory of Gene Detection & Therapy, Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Department of Immunology, School of Basic Medicine, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563000, China.
Xiaorong XuBiology and Medicine Program, School of Bioengineering, Zhuhai Campus, Zunyi Medical University, Zhuhai 519000, China.
Hailong SuSpecial Key Laboratory of Gene Detection & Therapy, Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Department of Immunology, School of Basic Medicine, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563000, China.ORCID 0000-0002-5091-4033
Ming QinSpecial Key Laboratory of Gene Detection & Therapy, Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Department of Immunology, School of Basic Medicine, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563000, China.
Junmin LuoSpecial Key Laboratory of Gene Detection & Therapy, Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Department of Immunology, School of Basic Medicine, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563000, China.

Funding

the Graduate Education Teaching Reform Project of Zunyi Medical University YJSKJJ20250228the Graduate Education Teaching Reform Project of Zunyi Medical University ZYK212the Science and Technology Project of Guizhou No. [2024]268
6 · The paper itself

Abstract

6PPD-Quinone (6PPD-Q) is a tire derivative formed by the oxidation of N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), a commonly used antioxidant and ozone stabilizer in rubber products, and has emerged as a significant environmental concern in recent years. It is widely present in the atmosphere, surface lakes, and soil. The primary routes of exposure to 6PPD-Q are the digestive tract and respiratory tract. Studies indicate that it is a major factor causing acute mortality in coastal coho salmon (

Indexed as

6PPD-Qecotoxicologyenvironmental toxicitymulti-organ toxicitytire derivatives

Identifiers

PMID42043115
PMCPMC13120373

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.