Evidence map›Paper›PMID 42043245›Full record

ReviewViruses2026

Molecular Mimics: How Viral Genomes Dupe Their Host by Usurping CTCF to Establish Infection.

Clairine I S Larsen, Rhiannon R Abrahams, Kinjal Majumder

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Clairine I S LarsenCellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Rhiannon R AbrahamsInstitute for Molecular Virology and McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0002-8988-7976
Kinjal MajumderInstitute for Molecular Virology and McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0002-1898-8251

Funding

Defining how cellular DNA replication and repair machinery are hijacked by viral pathogensR35GM154938 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Kinjal Majumder · 2024 to 2026
$1.1M
How does a viral pathogen manipulate DNA Damage Responses to promote infection?R00AI148511 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MAJUMDER, KINJAL · 2022 to 2023
$498k
How does a viral pathogen manipulate the DNA Damage Response to promote successful viral infection?K99AI148511 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MAJUMDER, KINJAL · 2020 to 2021
$207k
National Institute of Allergy and Infectious Diseases AI148511National Science Foundation DGE-2137424NIAID NIH HHS K99 AI148511NIAID NIH HHS R00 AI148511NIGMS NIH HHS GM154938NIGMS NIH HHS R35 GM154938University of Wisconsin-Madison ScimedGRSWisconsin Partnership Program G-4942
6 · The paper itself

Abstract

The eukaryotic genome is organized into distinct structural units dictated by architectural proteins. The major host architectural protein CCCTC-binding factor (CTCF) is usurped by DNA viruses to regulate viral gene expression. This review will discuss the major ways large (EBV, HSV, HCMV) and small (HPV, HBV, AAV) DNA viruses mimic eukaryotic genome topology using CTCF to regulate viral gene expression. We will further discuss how changes in genome topology can drive virally induced oncogenic progression. Knowledge gained from studying viral genome folding mechanisms will inform the development of targeted anti-viral agents and inform the modification of viruses to serve as gene therapy vectors.

Indexed as

CCCTC-Binding FactorDNA VirusesGenome, ViralMolecular MimicryAnimalsGene Expression Regulation, ViralHumansCCCTC-Binding FactorCTCF protein, humanchromosome conformation captureCTCFDNA virusesgene regulationinsulator

Identifiers

PMID42043245
PMCPMC13120354

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.