Evidence map›Paper›PMID 42044234›Full record

ArticleStroke2026

Design Matters: Challenges and Remedies in CREST-2.

George Howard, James F Meschia, Brajesh K Lal, Thomas G Brott

Abstract readComment
In one paragraph

Article in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. CREST-2 findings are unchanged using an aggregated control group for the CAS and CEA trial.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

George HowardDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham (G.H.).ORCID 0000-0002-3068-5720
James F MeschiaDepartment of Neurology, Mayo Clinic Florida, Jacksonville (J.F.M., T.G.B.).ORCID 0000-0002-4475-8142
Brajesh K LalDepartment of Vascular Surgery, University of Maryland, Baltimore (B.K.L.).ORCID 0000-0001-6724-8201
Thomas G BrottDepartment of Neurology, Mayo Clinic Florida, Jacksonville (J.F.M., T.G.B.).ORCID 0000-0002-1266-0941

Funding

CREST-2 Clinical Coordinating CenterU01NS080168 · NINDS · MAYO CLINIC JACKSONVILLE · PI Thomas G Brott, JAMES F MESCHIA · 2014 to 2026
$56.3M
CREST-2 Statistical and Data Coordinating Center - SDCCU01NS080165 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI EDWARDS, LLOYD J · 2014 to 2025
$15.0M
NINDS NIH HHS U01 NS080165NINDS NIH HHS U01 NS080168
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

carotid stenosisclinical trialendarterectomy, carotidprimary preventionstentsstroke

Identifiers

PMID42044234
PMCPMC13251720

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.