Resveratrol protects against triclosan-induced impairment of colonic barrier function in chickens.

Yixin Zhang, Huayu Zhang, Qiushi Li, Fucheng Wang, Tianning Luo, Qiaochu Sun, Wen Zhang

Abstract read

In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yixin ZhangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.

Huayu ZhangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.

Qiushi LiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.

Fucheng WangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.

Tianning LuoCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.

Qiaochu SunCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China.

Wen ZhangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, China. Electronic address: zhangwen@nefu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triclosan (TCS) is a widely used antimicrobial agent, and chronic exposure has been reported to impair intestinal barrier function and induce oxidative stress and inflammation. Resveratrol (RSV), a natural polyphenolic compound with antioxidant and anti-inflammatory properties, may protect against TCS-induced intestinal injury. This study investigated the protective effects of RSV on TCS-induced colonic damage in chickens and the underlying mechanisms. In a 4-week trial, 100 10-week-old chickens were randomly assigned to five groups (n = 20 per group): control (CON), solvent control (VCON), TCS (150 mg/kg), RSV (400 mg/kg), and TCS+RSV. To evaluate the protective effects, we measured colonic morphology, barrier-related proteins, serum markers, oxidative stress indicators, and mitochondrial biogenesis and dynamics signaling. Data were analyzed using one-way ANOVA, and significance was set at P < 0.05. Results showed TCS significantly damaged colonic structure and impaired barrier function, alongside increased inflammation and mitochondrial dysregulation (P < 0.05). RSV supplementation markedly mitigated these effects by restoring morphology, upregulating tight junction proteins and MUC2, and reducing serum d-lactate and DAO levels. Mechanistically, RSV suppressed NLRP3 inflammasome activation, enhanced antioxidant capacity via the Nrf2/HO-1 pathway, and normalized the SIRT1/PGC-1α axis to preserve mitochondrial homeostasis (P < 0.05). These findings suggest that RSV may serve as a potential dietary strategy to protect intestinal health in poultry under environmental contaminant exposure.

Indexed as

Anti-Infective Agents, LocalAntioxidantsChickensColonProtective AgentsResveratrolTriclosanAnimal FeedAnimalsDietDietary SupplementsIntestinal Barrier FunctionMaleOxidative StressRandom AllocationAnti-Infective Agents, LocalAntioxidantsProtective AgentsResveratrolTriclosanChickenColonResveratrolSIRT1/PGC–1αTriclosan

Identifiers

PMID42044597

DOI10.1016/j.psj.2026.106946

PMCPMC13133934

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.