A Zeolitic Pyrimidine Framework (ZPF) Nanoplatform Co-Delivers a DNAzyme and a Protein Prodrug for Cascade-Activated Tumour Therapy.

Yan Huang, Xingjie Hu, Jinli Sun, Min Yin, Nan Chen

Abstract read

In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yan HuangShanghai Engineering Research Center of Green Energy Chemical Engineering, Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Frontiers Science Center of Biomimetic Catalysis, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, China.

Xingjie HuState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Jinli SunState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Min YinShanghai Engineering Research Center of Green Energy Chemical Engineering, Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Frontiers Science Center of Biomimetic Catalysis, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, China.

Nan ChenShanghai Engineering Research Center of Green Energy Chemical Engineering, Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Frontiers Science Center of Biomimetic Catalysis, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, China.ORCID https://orcid.org/0000-0001-8536-6631

Funding

National Natural Science Foundation of China 21974089Natural Science Foundation of Shanghai municipality 24ZR1455600

6 · The paper itself

Abstract

The therapeutic application of cytotoxic proteins like ribonuclease A (RNase A) is hindered by their systemic toxicity. Here, we engineer a protein-structure-directed zeolitic pyrimidine framework (ZPF) as a superior nanocarrier that co-encapsulates and stabilizes a ROS-responsive RNase A prodrug (RNBC) and a GPX-1-targeting DNAzyme with high efficiency. This DZ-RNBC@ZPF nanocomplex, camouflaged with a 4T1 cell membrane, ensures tumour-specific delivery and lysosomal degradation. The acidic environment triggers framework dissolution, releasing Zn

Indexed as

cascade activationDNAzymeROS‐responsive prodrugsynergistic therapytargeted protein therapyzeolitic pyrimidine framework (ZPF)

Identifiers

PMID42044641

DOI10.1111/cpr.70225

PMCPMC13325916

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.