Evidence map›Paper›PMID 42045194›Full record

ArticleNature communications2026

Epitranscriptomic regulation of mRNA stability in pivotal transcription factors modulates the second cell fate decision.

Weide Xiao, Li Tang, Mingli Ma, Kuisheng Liu, Jiaxu Lu, Wenqing Ding, Zhile Bai, Xuelian Liu, Xiaochen Kou, Yanhong Zhao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Weide Xiao *Department of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.ORCID http://orcid.org/0000-0002-1456-4240
Li Tang *State Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Mingli Ma *Department of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Kuisheng Liu *Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Jiaxu LuDepartment of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Wenqing DingState Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Zhile BaiDepartment of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Xuelian LiuDepartment of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Xiaochen KouDepartment of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Yanhong ZhaoDepartment of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Hong WangDepartment of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Lei YangDepartment of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Shaorong GaoDepartment of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. gaoshaorong@tongji.edu.cn.ORCID http://orcid.org/0000-0003-1041-3928
Yawei GaoDepartment of Reproductive Medicine Center, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. gaoyawei@tongji.edu.cn.ORCID http://orcid.org/0000-0001-8946-9697
Jun LiuState Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. junliu1223@pku.edu.cn.ORCID http://orcid.org/0000-0002-2498-9963

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32170595
6 · The paper itself

Abstract

Embryonic development demands precise coordination of transcriptional and post-transcriptional mechanisms to ensure rapid cell fate transitions, yet the molecular mechanisms by which RNA influences these transitions remain unclear. Here, we observed a global increase in mRNA stability during the blastocyst formation, which precedes rapid lineage specification. Using both in vivo and mouse totipotent blastomere-like cells (TBLCs) or extended pluripotent stem cells (EPSCs) differentiation systems, we demonstrate that this transcriptome-wide stabilization is essential for the second cell fate decision, particularly in the formation of primitive endoderm (PrE). Mechanistically, VIRMA and METTL3, the components of methyltransferase complex (MTC) establish lineage specification by stabilizing the key PrE transcription factors, including Gata6, via the N

Indexed as

RNA StabilityTranscription FactorsAdenosineAnimalsBlastocystBlastomeresCell DifferentiationCell LineageEmbryonic DevelopmentEndodermEpitranscriptomeEpitranscriptomicsGATA6 Transcription FactorGene Expression Regulation, DevelopmentalMethyltransferasesMiceAdenosineGata6 protein, mouseGATA6 Transcription FactorMethyltransferasesMettl3 protein, mouseN-methyladenosineRNA-Binding ProteinsRNA, MessengerTranscription Factors

Identifiers

PMID42045194
PMCPMC13332025

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.