Evidence map›Paper›PMID 42045465›Full record

ArticleNature neuroscience2026

Brain motion is driven by mechanical coupling with the abdomen.

C Spencer Garborg, Beatrice Ghitti, Qingguang Zhang, Joseph M Ricotta, Noah Frank, Sara J Mueller, Denver I Greenawalt, Kevin L Turner, Ravi T Kedarasetti, Marceline Mostafa and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

C Spencer GarborgPenn State Neuroscience Institute - University Park, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0002-2623-4054
Beatrice GhittiDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0002-8769-2454
Qingguang ZhangPenn State Neuroscience Institute - University Park, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0003-4500-813X
Joseph M RicottaPenn State Neuroscience Institute - University Park, The Pennsylvania State University, University Park, PA, USA.
Noah FrankDepartment of Mechanical Engineering, The Pennsylvania State University, University Park, PA, USA.
Sara J MuellerCenter for Quantitative Imaging, The Pennsylvania State University, University Park, PA, USA.
Denver I GreenawaltPenn State Neuroscience Institute - University Park, The Pennsylvania State University, University Park, PA, USA.
Kevin L TurnerPenn State Neuroscience Institute - University Park, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0002-3044-7079
Ravi T KedarasettiCenter for Neural Engineering, The Pennsylvania State University, University Park, PA, USA.
Marceline MostafaDepartment of Biology, The Pennsylvania State University, University Park, PA, USA.
Hyunseok LeePenn State Neuroscience Institute - University Park, The Pennsylvania State University, University Park, PA, USA.
Francesco CostanzoCenter for Neural Engineering, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0003-3169-9638
Patrick J DrewPenn State Neuroscience Institute - University Park, The Pennsylvania State University, University Park, PA, USA. pjd17@psu.edu.ORCID http://orcid.org/0000-0002-7483-7378

Funding

Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Laura Diane Lewis · 2022 to 2026
$13.6M
Imaging neurovascular coupling and functional connectivity in the behaving mouseR01NS078168 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI DREW, PATRICK JAMES · 2013 to 2023
$3.3M
Research Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2M
Nasal uptake of polystyrene nanoplastics into the murine central nervous systemF31ES036154 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Denver Greenawalt · 2024 to 2026
$110k
American Heart Association (American Heart Association, Inc.) 935961American Heart Association-American Stroke Association 935961NIEHS NIH HHS F31 ES036154NIGMS NIH HHS T32 GM108563NINDS NIH HHS R01 NS078168NINDS NIH HHS U19 NS128613Pennsylvania Department of Health (PDH) 4100095613U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) F31ES036154U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM108563U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS078168U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U19NS128613
6 · The paper itself

Abstract

The brain moves within the skull, but the drivers and consequences of this motion are not well understood. Here we visualized motion of the dorsal cortex relative to the skull in awake head-fixed mice using high-speed, multiplane two-photon microscopy. Brain motion was directed primarily rostrally and laterally, and was correlated tightly with locomotion, but not with respiration or the cardiac cycle. Specifically, brain motion was driven by abdominal muscle contractions that activate a hydraulic-like vascular connection between the nervous system and the abdominal cavity, and could similarly be induced by pressure applied to the abdomen. Model simulations suggest that brain motion may drive interstitial fluid through and out of the brain into the subarachnoid space, in the opposite direction of fluid flow seen during sleep. These results suggest that the brain is linked mechanically to the abdominal compartment, and that fluid flow in the brain could be coupled to body movements.

Indexed as

AbdomenBrainAbdominal MusclesAnimalsLocomotionMaleMiceMice, Inbred C57BLMovement

Identifiers

PMID42045465
PMCPMC13246511

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.