ArticleBMC medical imaging2026
Associations among thyroid function, white matter microstructure, and emotional disturbances in thyroid eye disease.
Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesTo characterize white matter microstructural abnormalities in thyroid eye disease (TED) using tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI), and to explore their associations with thyroid function and emotional disturbances.
methods24 TED patients and 27 age-, sex-, and education-matched healthy controls (HC) were enrolled. DTI- and DKI-derived maps were analyzed using TBSS to obtain voxel-wise measures of fractional anisotropy (FA) and mean kurtosis (MK). Correlation analyses were performed among diffusion metrics, thyroid function indices, and psychological state assessment questionnaire scores. Mediation analysis was conducted to further understand the relationships between these variables.
resultsCompared with DTI, TBSS analysis of DKI revealed more extensive white matter abnormalities in TED after correction for multiple comparisons. TED patients showed significantly reduced MK values in multiple predominantly left-sided white matter tracts and the corpus callosum, whereas FA showed no significant corrected differences. Lower MK values were associated with lower thyroid function levels and greater emotional disturbances. Exploratory mediation analyses identified significant indirect effects linking thyroid function with emotional disturbances through altered white matter tracts.
conclusionsTED is associated with subtle white matter microstructural abnormalities detectable by DKI, particularly in predominantly left-sided tracts. Altered white matter integrity showed exploratory associations with thyroid hormone levels and emotional disturbances and may represent a potential correlate of their relationship in TED.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.