ArticleLipids in health and disease2026
Atherogenic index of plasma in early pregnancy: associations with gestational diabetes mellitus and preeclampsia and its mediating role.
Article in Lipids in health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundGestational diabetes mellitus (GDM) and preeclampsia (PE) are severe complications that significantly impact maternal and fetal well-being. Although their clinical association is well-established, the role of dyslipidemia remains unclear. The objective of this investigation was to characterize a readily available lipid indicator that functions as both an early predictor and a mediator of the link between GDM and PE, thereby supporting timely clinical intervention.
methodsA total of 1858 singleton pregnant women recruited from Eastern and Western China were included in this study. Fasting serum lipid profiles were collected during the first trimester (between the 10th and 14th weeks). Lasso regression and the Boruta algorithm were used to identify an optimized lipid-derived predictor for PE. Additionally, association and mediation modeling were implemented to evaluate the contribution of the selected lipid marker to the GDM-PE association.
resultsThe mean age of all participants was 30 (27, 33) years. The atherogenic index of plasma (AIP), total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were the only lipid-related variables identified at the intersection of Lasso and Boruta analyses as candidate predictors for PE. In the GDM with PE group, AIP was significantly higher than in other subgroups, whereas TC and HDL-C were not. A high first-trimester AIP emerged as an independent risk factor for both GDM (adjusted odds ratio [aOR]: 1.74; 95% confidence interval [CI]: 1.33 to 2.27, P < 0.001) and PE (aOR: 2.38; 95% CI: 1.10 to 5.15, P = 0.028). Restricted cubic splines (RCS) analysis revealed a significant nonlinear association between AIP and the risk of GDM, and a linear association with PE. Crucially, mediation analysis demonstrated that AIP significantly mediated the association between GDM and PE, accounting for 31.45% of the total effect (P = 0.012), a proportion exceeding that of other lipid parameters such as triglyceride (TG) (29.58%).
conclusionsThese results demonstrate that early-pregnancy AIP predicts a greater susceptibility to both GDM and PE, while functioning as a critical mediator of their pathological interrelationship. These observations highlight AIP as a highly accessible and cost-effective indicator for stratifying PE risk, offering a practical strategy to mitigate severe obstetric complications and enhance global maternal health outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.