Evidence map›Paper›PMID 42047683›Full record

ArticleeLife2026

Interrogating the structure and function of the human voltage-gated proton channel (hH

Emerson M Carmona, William N Zagotta, Sharona E Gordon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Emerson M CarmonaDepartment of Neurobiology and Biophysics, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0003-1332-0372
William N ZagottaDepartment of Neurobiology and Biophysics, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0002-7631-8168
Sharona E GordonDepartment of Neurobiology and Biophysics, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0002-0914-3361

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1985 to 2026
$23.5M
GATING MECHANISMS OF RETINAL ROD CGMP-ACTIVATED CHANNELSR01EY010329 · NEI · UNIVERSITY OF WASHINGTON · PI ZAGOTTA, WILLIAM N · 1994 to 2023
$7.7M
Conformational Energetics and Heterogeneity to Reveal Gating Mechanisms of TRPV and TRPM Ion ChannelsR35GM145225 · NIGMS · UNIVERSITY OF WASHINGTON · PI Sharona E Gordon · 2022 to 2026
$3.4M
Structural energetics of voltage- and ligand-dependent gating in ion channelsR35GM148137 · NIGMS · UNIVERSITY OF WASHINGTON · PI William N Zagotta · 2023 to 2026
$2.0M
Chemical Biology Probes to Decipher Regulation of TRPV1 in Living CellsR01EY037223 · NEI · UNIVERSITY OF WASHINGTON · PI Sharona E Gordon · 2025 to 2026
$1.4M
NEI NIH HHS P30 EY001730NIDDK NIH HHS P30 DK017047NIGMS NIH HHS R35 GM145225NIH HHS R01EY010329NIH HHS R01EY037223NIH HHS R35GM145225NIH HHS R35GM148137
6 · The paper itself

Abstract

The human voltage-gated proton channel (hH

Indexed as

Amino AcidsIon ChannelsEscherichia coliFluorescence Resonance Energy TransferHumansProtein ConformationProtonsAmino AcidsHVCN1 protein, humanIon ChannelsProtonsacridonylalaninebiochemistrychemical biologyE. colifluorescenceFRETgenetic code expansionhumanmolecular biophysicsstructural biologyvoltage-gated proton channel

Identifiers

PMID42047683
PMCPMC13124150

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.