ArticleMolecular biology reports2026
IL-27-964 A/G polymorphism promoter polymorphism, serum IL-27, and vitamin D in multiple sclerosis: evidence from an egyptian case-control study.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMultiple sclerosis (MS) is a disabling central nervous system immune-mediated disease, which is motivated by complicated gene-environment connections. The IL-27 (rs153109 -964 A G) functional promoter variant could affect the expression of IL-27, and consequently the susceptibility. to MS. Nonetheless, the synergy between IL-27 polymorphism (rs153109), serum IL-27 levels, and vitamin D status in the susceptibility of MS in the Middle East has not been completely clarified, especially in the Middle East. METHODS AND
resultsThis was a case-control study of 100 patients with multiple sclerosis and 100 healthy controls of ethnicity and geography matching the patients. PCR-RFLP was used to genotype IL-27 rs153109. ELISA was used to determine serum IL-27 levels, and a particle-enhanced immunoturbidimetric assay was used to determine vitamin D3 levelsThe GG genotype of IL-27 rs153109 was significantly more frequent in MS patients compared to controls (22% vs 12%) and was associated with an increased risk of MS (OR = 2.724, 95% CI: 1.195-6.207; p = 0.017). Similarly, carriage of the G allele was linked to higher susceptibility (OR = 1.796, 95% CI: 1.190-2.711; p =0.005). MS patients exhibited significantly lower serum IL-27 levels (median: 20.7 vs 25.3 pg/mL; p ≤ 0.001) and lower vitamin D3 levels (median: 20.0 vs 26.9 ng/mL; p ≤ 0.001) compared with controls, with no significant differences observed across genotypes. Regarding clinical and lifestyle factors, smoking (OR = 3.209; p = 0.019) and overweight (OR = 2.006; p = 0.037) were significantly associated with MS risk. In multivariable analysis, the rs153109 GG genotype (OR = 3.115; p = 0.019), smoking (OR = 3.294; p = 0.024), and overweight (OR = 2.610; p = 0.039) remained independent predictors.
conclusionThe IL-27-964 A/G polymorphism, especially the GG and G allele carriers, is strongly related to the predisposition to multiple sclerosis. Moreover, genotype independent low levels of serum IL-27 and vitamin D were observed in MS patients. These results indicate the possible role of IL-27 genetic variation in the pathogenesis of MS and contribute to the role of IL-27-mediated immune pathways. Additional confirmation in bigger and longitudinal studies.
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