Evidence map›Paper›PMID 42047745›Full record

ReviewBiogerontology2026

Sirtuin 1 as an emerging exerkine in the aging process: unveiling its multifaceted biological roles.

Patrício Lopes de Araújo Leite, Larissa Alves Maciel, Rita Cristine Barboza Patricio, Geovanna Lopes Carneiro Pereira, Antônio Sérgio de Oliveira Lamounier, Samuel da Silva Aguiar, Caio Victor Sousa, Ivo Vieira de Sousa Neto, Herbert Gustavo Simões

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patrício Lopes de Araújo LeiteGraduate Program in Physical Activity, Health, and Human Performance, Catholic University of Brasilia (UCB), EPTC QS 7 LT 1, Bloco G, Sala G116, Taguatinga, DF, 72.022-900, Brazil. patriciolopesdearaujoleite@gmail.com.
Larissa Alves MacielGraduate Program in Physical Activity, Health, and Human Performance, Catholic University of Brasilia (UCB), EPTC QS 7 LT 1, Bloco G, Sala G116, Taguatinga, DF, 72.022-900, Brazil.
Rita Cristine Barboza PatricioGraduate Program in Physical Therapy, University of Brasília (UNB), Ceilândia, Brazil.
Geovanna Lopes Carneiro PereiraGraduate Program in Medicine, Catholic University of Brasilia (UCB), Taguatinga, DF, Brazil.
Antônio Sérgio de Oliveira LamounierGraduate Program in Medicine, Catholic University of Brasilia (UCB), Taguatinga, DF, Brazil.
Samuel da Silva AguiarGraduate Program in Physical Activity, Health, and Human Performance, Catholic University of Brasilia (UCB), EPTC QS 7 LT 1, Bloco G, Sala G116, Taguatinga, DF, 72.022-900, Brazil.
Caio Victor SousaDepartment of Health and Human Sciences, Loyola Marymount University, Los Angeles, USA.
Ivo Vieira de Sousa NetoSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Herbert Gustavo SimõesGraduate Program in Physical Activity, Health, and Human Performance, Catholic University of Brasilia (UCB), EPTC QS 7 LT 1, Bloco G, Sala G116, Taguatinga, DF, 72.022-900, Brazil. hgsimoes@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sirtuin 1 (SIRT1) was initially identified as an enzyme that deacetylates histones and suppresses gene activity. Since then, its roles have expanded considerably, and it is now recognized as a multifunctional protein conserved across various organisms. Despite increasing interest, it remains essential to clarify how exercise-induced changes in SIRT1 counteract multiple hallmarks of aging, as well as the full scope of SIRT1's impact on different physiological systems. This review highlights recent findings on the short- and long-term effects of exercise on SIRT1 signaling in both rodents and humans during aging. We explore the molecular pathways activated in various tissues, providing insight into the specific biological functions of SIRT1 within aging cells. Optimal levels of SIRT1 help maintain homeostasis and a biochemical environment conducive to healthspan, influencing biological processes such as mitochondrial dynamics, metabolic pathways, tissue remodeling, autophagy, inflammatory responses, and redox balance. This indicates that SIRT1, a pleiotropic molecule, orchestrates multiple responses throughout aging. SIRT1 may act as a dynamic sensor for exercise benefits and protect against aging by maintaining genomic integrity. Different exercise protocols (acute and chronic) and modalities (aerobic, resistance, and combined training) can increase mRNA levels, activity, or protein levels of SIRT1 in various vital organs (adipose tissue, hippocampus, heart, liver, bone, and skeletal muscle) of aged animals and older adults, promoting health. Taken together, these observations support the notion that SIRT1 functions as a potential exerkine, and understanding its role in exercise-induced adaptations offers new insights into non-pharmacological strategies to enhance longevity.

Indexed as

AgingExerciseSirtuin 1AnimalsHumansSignal TransductionSIRT1 protein, humanSirtuin 1AgingPhysical exerciseSenescenceSirtuins

Identifiers

PMID42047745
PMCPMC13124835

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.