Evidence map›Paper›PMID 42048655›Full record

ArticleBiochemistry2026

Molecular Basis of α-Glycine C-H Activation by a Nonheme Fe(II)/2-Oxoglutarate Dioxygenase.

Manyun Chen, Thisuri N Wanniarachchi, Jonathan D Caranto, Gustavo Seabra, Steven D Bruner, Yousong Ding

Abstract read
In one paragraph

Article in Biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manyun ChenDepartment of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-6803-044X
Thisuri N WanniarachchiDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Jonathan D CarantoDepartment of Chemistry, University of Central Florida, Orlando, Florida 32816, United States.ORCID 0000-0002-9196-5275
Gustavo SeabraDepartment of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-1303-4483
Steven D BrunerDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0002-0522-480X
Yousong DingDepartment of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-8610-0659

Funding

Integrative Multidisciplinary Discovery Platform to Unlock Marine Natural Products Therapeutic OpportunitiesRM1GM145426 · NIGMS · UNIVERSITY OF FLORIDA · PI Mohamed Abou Donia, Steven D Bruner · 2022 to 2026
$8.8M
NIH Equipment Supplement to R35GM128742R35GM128742 · NIGMS · UNIVERSITY OF FLORIDA · PI Yousong Ding · 2018 to 2026
$3.4M
Mechanisms of novel biological nitrogen chemistriesR35GM147515 · NIGMS · UNIVERSITY OF CENTRAL FLORIDA · PI Jonathan D Caranto · 2022 to 2026
$1.8M
NIGMS NIH HHS R35 GM128742NIGMS NIH HHS R35 GM147515NIGMS NIH HHS RM1 GM145426
6 · The paper itself

Abstract

Nonheme Fe(II)/2-oxoglutarate (Fe/2-OG) dioxygenases carry out a broad range of oxidative reactions, yet α-hydroxylation of glycyl residues remains exceedingly rare. Here, we demonstrate that the Fe/2-OG enzyme MysH from

Indexed as

Bacterial ProteinsDioxygenasesGlycineMixed Function OxygenasesNostocCatalytic DomainCrystallography, X-RayHydroxylationKetoglutaric AcidsKineticsMolecular Docking SimulationMolecular Dynamics SimulationMutagenesis, Site-DirectedSubstrate SpecificityBacterial ProteinsDioxygenasesGlycineKetoglutaric AcidsMixed Function Oxygenases

Identifiers

PMID42048655
PMCPMC13170491

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.