Evidence map›Paper›PMID 42049863›Full record

ArticleScientific reports2026

Elucidating the anti-colorectal cancer mechanism of Physalis Calyx seu Fructus extract via mass spectrometry-molecular networking and bioinformatics.

Zikai Guo, Tao Jiang, Xiaoran Wang, Xingyao Li, Anqi Luo, Weihan Li, Yan Xiao, Yumei He, Yisong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zikai Guo *Hunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Tao Jiang *Academician Workstation, Jiangxi University of Chinese Medicine, Nanchang, 330004, China. jiangtao@jxutcm.edu.cn.
Xiaoran WangHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Xingyao LiHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Anqi LuoHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Weihan LiHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Yan XiaoHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Yumei HeAcademician Workstation, Jiangxi University of Chinese Medicine, Nanchang, 330004, China.
Yisong LiuHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China. liuyisong@hunau.edu.cn.

Funding

Natural Science Foundation of Changsha kq2202232Research Foundation of the Education Bureau of Hunan Province 22A0146Research Foundation of the Education Bureau of Hunan Province 23C0089
6 · The paper itself

Abstract

Chemical profiling combined with computational analysis highlighted luteolin and chrysoeriol as candidate anti-colorectal cancer (CRC) compounds in Physalis Calyx seu Fructus (PCF) extract, potentially associated with MMP9 and CDK1. Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) generated 23 annotated MS entries from PCF extracts, while bioinformatics analysis of Gene Expression Omnibus (GEO) datasets revealed 867 CRC-dysregulated genes. Weighted gene co-expression network analysis (WGCNA) and machine learning prioritized 397 core CRC genes enriched in cell cycle regulation, with CDK1 and MMP9 as top hubs. Network pharmacology mapped PCF-related compounds to 468 CRC targets, identifying 25 overlapping targets with core genes. Molecular docking showed that the putatively annotated compounds luteolin and chrysoeriol exhibited favorable binding to MMP9 and CDK1, respectively. 100-ns molecular dynamics (MD) simulations suggested structural stability for both complexes (RMSD: 2.7-2.8 Å). These findings suggest that luteolin- and chrysoeriol-related features may contribute to the anti-CRC potential of PCF by affecting cell-cycle-associated targets, although further experimental validation is required.

Indexed as

PhysalisPlant ExtractsCDC2 Protein KinaseComputational BiologyFruitGene Expression Regulation, NeoplasticHumansLuteolinMass SpectrometryMatrix Metalloproteinase 9Molecular Docking SimulationMolecular Dynamics SimulationCDC2 Protein KinaseLuteolinMatrix Metalloproteinase 9Plant ExtractsbioinformaticsCDK1/MMP9 inhibitionColorectal cancerLuteolinMass spectrometry-molecular networkPhysalis Calyx seu Fructus

Identifiers

PMID42049863
PMCPMC13316035

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.