Evidence map›Paper›PMID 42049921›Full record

ArticleScientific reports2026

Specific elimination of m.8993T>G mitochondrial haplotype in NARP cybrid cells by CRISPR-Cas9 system.

Elvira Zakirova, Svetlana Sergeeva, Ksenia Morozova, Elena Kiseleva, Masashi Tanaka, Ilya Mazunin, Konstantin Orishchenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elvira ZakirovaFederal Research Center Institute of Cytology and Genetics, Novosibirsk, 630090, Russia.
Svetlana SergeevaFederal Research Center Institute of Cytology and Genetics, Novosibirsk, 630090, Russia.
Ksenia MorozovaFederal Research Center Institute of Cytology and Genetics, Novosibirsk, 630090, Russia.
Elena KiselevaFederal Research Center Institute of Cytology and Genetics, Novosibirsk, 630090, Russia.
Masashi TanakaDepartment of Neurology, Juntendo University Graduate School of Medicine, Tokyo, 113- 8421, Japan.
Ilya Mazunin *The Center for Bio- and Medical Technologies, Moscow, 121205, Russia.
Konstantin Orishchenko *Federal Research Center Institute of Cytology and Genetics, Novosibirsk, 630090, Russia. OrishchenkoKE@icg.sbras.ru.

Funding

Ministry of Science and Higher Education of the Russian Federation FSUS-2024-0018Ministry of Science and Higher Education of the Russian Federation FWNR-2026-0024Russian Science Foundation 23-45-10010
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CRISPR-SpCas9Heteroplasmy shiftm.8993T>G point mutationMitochondriaNARP syndrome

Identifiers

PMID42049921
PMCPMC13316044

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.