Evidence map›Paper›PMID 42049997›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Lp-PLA2-derived LysoPC drives dendritic cell immunogenic activation and Th17 inflammation in severe asthma.

Fang Wang, Zhihui Min, Yuhao Qian, Jiameng Gao, Zhenlin Yang, Zhilong Jiang, Zhihong Chen

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fang WangDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhihui MinBiomedical Research Center of Zhongshan Hospital, Fudan University, Shanghai, China.
Yuhao QianDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiameng GaoDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhenlin YangDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhilong JiangDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. Jiang.zhilong@zs-hospital.sh.cn.
Zhihong ChenDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. chenzhihong@xinhuamed.com.cn.

Funding

National Natural Science Foundation of China 82270026National Natural Science Foundation of China 82370082Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0506305
6 · The paper itself

Abstract

Severe asthma (SA) is associated with dysregulated phospholipid metabolism, yet the underlying immunometabolic mechanisms remain poorly understood. Our metabolomic profiling of SA patients revealed a characteristic remodeling of the phosphatidylcholine (PC)-lysophosphatidylcholine (LysoPC) axis, featuring an accumulation of long-chain PC precursors and a depletion of polyunsaturated lipids. In a murine model of severe neutrophilic asthma, we identified explosive localized generation of pathogenic saturated LysoPC (particularly the 16:0 species) driven by hyperactive PC hydrolysis. Mechanistically, LysoPC acts as an endogenous danger signal that promotes the immunogenic activation of dendritic cells (DCs) by inducing a signaling "seesaw" of concurrent NF-κB activation and p38 MAPK suppression, thereby driving na ïve CD4

Indexed as

1-Alkyl-2-acetylglycerophosphocholine EsteraseAsthmaDendritic CellsLysophosphatidylcholinesPhosphatidylcholinesTh17 CellsAnimalsFemaleHumansInflammationMaleMiceMice, Inbred C57BL1-Alkyl-2-acetylglycerophosphocholine EsteraseLysophosphatidylcholinesPhosphatidylcholinesDendritic cellsLp-PLA2LysoPCSevere asthmaTh17 cells

Identifiers

PMID42049997

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.