Evidence map›Paper›PMID 42050794›Full record

ArticleInternational journal of cancer2026

Mental Health Conditions and Incident Cancer: A Prospective Cohort Study of 402,255 UK Biobank Participants.

Mohammed Sherif Amin, Solange Parra-Soto, Ziyi Zhou, Shinya Nakada, Ike Dhiah Rochmawati, Carlos Celis-Morales, Nancy Meligy, Jill P Pell, Frederick K Ho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammed Sherif AminDepartment of Clinical Infection, Microbiology, and Immunology, The University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0009-0009-7228-830X
Solange Parra-SotoDepartment of Nutrition and Public Health, Faculty of Health Science and Food, Universidad del Bío-Bío, Chillán, Chile.
Ziyi ZhouSchool of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Shinya NakadaSchool of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Ike Dhiah RochmawatiSchool of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Carlos Celis-MoralesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Nancy MeligyFaculty of Medicine, Health and Life Sciences, Swansea University, Swansea, UK.
Jill P PellSchool of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Frederick K HoSchool of Health and Wellbeing, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0001-7190-9025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mental health conditions (MHCs) affect both psychological health and biological systems and have also been linked to cancer risk. However, evidence from epidemiological studies regarding this link remains inconsistent. We conducted a population-based prospective cohort study involving 402,255 UK Biobank participants to investigate the associations of five MHCs (depressive disorders [DD], anxiety disorders [AD], bipolar disorder [BD], schizophrenia [SZ] and post-traumatic stress disorder [PTSD]) with overall and site-specific cancer risk. Cox proportional hazard models were used, adjusting for sociodemographic, health-related and lifestyle confounders. Over a median follow-up of 13.4 years, 68,065 (17%) incident cancer cases were recorded. DD (HR 1.18; 95% CI 1.13-1.23), AD (HR: 1.17, 95% CI: 1.11-1.24) and BD (HR: 1.29, 95% CI: 1.11-1.51) were associated with increased overall cancer risk. No significant association was found for SZ and PTSD. The associations of DD (HR: 1.27, 95% CI: 1.18-1.35) and BD (HR: 1.54, 95% CI: 1.26-1.88) were only significant in men. AD and DD were positively associated with lung, blood and liver cancers, while AD was also associated with prostate cancer. A dose-response relationship was observed between depressive symptom severity and cancer risk. While we cannot assume causality, our finding suggests that diagnoses of MHCs could be useful for cancer risk stratification and prevention.

Indexed as

Mental DisordersNeoplasmsAdultAgedAnxiety DisordersBiological Specimen BanksBipolar DisorderDepressive DisorderFemaleHumansIncidenceMaleMental HealthMiddle AgedProportional Hazards ModelsProspective Studiesanxietybipolar disorderscancer epidemiologydepressionsevere mental illness

Identifiers

PMID42050794
PMCPMC13397219

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.