SynthesisFrontiers in public health2026
Association between frailty and depression in older adults with coronary heart disease: a systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Frailty Syndrome and Depressive Symptoms in Patients with Ischemic Heart Disease.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Frailty and depression frequently co-occur in older patients with coronary heart disease (CHD) and are each associated with adverse outcomes. However, the strength and nature of their association in this population have not been systematically quantified. Methods: We systematically searched PubMed, Embase, and Web of Science and other major databases from inception to April 2025 for observational studies examining the association between frailty and depression in adults with CHD. Two reviewers independently screened studies, extracted data, and assessed quality using the Newcastle-Ottawa Scale for cohort studies and the AHRQ checklist for cross-sectional studies. Both cross-sectional and cohort studies were eligible. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model, prioritizing adjusted estimates where available. Heterogeneity was quantified using the Results: Of 2,160 records screened, 6 studies met the inclusion criteria, comprising 2,628 patients with CHD. All included studies focused on older adults (mean/median age ≥60 years), reflecting the current evidence base in this population. Meta-analysis showed a significant positive association between frailty and depression (pooled OR = 2.45; 95% CI: 1.22-4.92), with substantial heterogeneity ( Conclusion: Frailty and depression are significantly associated in older adults with CHD, supporting integrated screening approaches. However, given the predominance of cross-sectional data, high heterogeneity, and limited cohort evidence, prospective studies are needed to establish temporality and better inform causal inference. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251036929, PROSPERO (CRD420Ò51036929).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.