Evidence mapPaperPMID 42052178Full record

ArticleRSC advances2026

Novel piperazine-triazole hybrids as PTP1B and alpha-amylase inhibitors: synthesis, biological evaluation and computational validation through network pharmacology, molecular docking, MD simulations, DFT and MMPBSA analysis.

Muhammad Haroon, Shagufta Kamal, Asim Mansha, Ameer Fawad Zahoor

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Muhammad HaroonDepartment of Chemistry, Government College University Faisalabad Faisalabad 38000 Pakistan fawad.zahoor@gcuf.edu.pk.ORCID https://orcid.org/0009-0000-2803-4630
Shagufta KamalDepartment of Biochemistry, Government College University Faisalabad Faisalabad 38000 Pakistan.
Asim ManshaDepartment of Chemistry, Government College University Faisalabad Faisalabad 38000 Pakistan fawad.zahoor@gcuf.edu.pk.
Ameer Fawad ZahoorDepartment of Chemistry, Government College University Faisalabad Faisalabad 38000 Pakistan fawad.zahoor@gcuf.edu.pk.ORCID https://orcid.org/0000-0003-2127-8848

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inhibition of α-amylase and PTP1B is essential for controlling hyperglycemia and improving insulin signaling. In this study, a series of piperazine conjugates were synthesized in 61-78% yields. All compounds were biologically screened against α-amylase to assess their anti-diabetic potential. Among these, compounds with Cl and OMe substitutions showed exceptional enzyme inhibition with IC

Identifiers

PMID42052178
PMCPMC13117338

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.