ArticleRSC advances2026
Novel piperazine-triazole hybrids as PTP1B and alpha-amylase inhibitors: synthesis, biological evaluation and computational validation through network pharmacology, molecular docking, MD simulations, DFT and MMPBSA analysis.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
The inhibition of α-amylase and PTP1B is essential for controlling hyperglycemia and improving insulin signaling. In this study, a series of piperazine conjugates were synthesized in 61-78% yields. All compounds were biologically screened against α-amylase to assess their anti-diabetic potential. Among these, compounds with Cl and OMe substitutions showed exceptional enzyme inhibition with IC
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