ArticleClinical neuropsychiatry2026
Association Between Serum Adropin Levels and Cognitive Impairment in the Elderly: A Cross-Sectional Study.
Article in Clinical neuropsychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Despite promising data from rodent models demonstrating a link between adropin deficiency and cognitive dysfunction, in-depth examinations of such an association in humans are lacking. Accordingly, the present study investigated the relationship between serum adropin levels and cognitive function in a sample of elderly individuals. Method: This cross-sectional study included 90 elderly (≥ 65 years of age) participants from geriatric outpatient clinics at Mansoura University (Mansoura City, Egypt), who were classified with normal cognition, mild neurocognitive disorder/mild cognitive impairment, or major neurocognitive disorder/dementia according to criteria from the Diagnostic and Statistical Manual of Psychiatric Disorders, Fifth Edition. Assessments included a comprehensive geriatric evaluation, cognitive testing, and measurement of serum adropin levels and metabolic parameters. Results: Multivariate regression (R Conclusions: Lower serum adropin levels were significantly associated with cognitive impairment in elderly individuals, with strong diagnostic discriminative ability (area under the receiver operating characteristic curve, 0.993). However, larger-scale longitudinal studies are required to establish causality and validate these findings.
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