ArticleInternational journal of hypertension2026
IFN-γ and IL-17A Exhibit Opposing Roles in Age-Related Blood Pressure Dysregulation.
Article in International journal of hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- IFN-γ and IL-17A Exhibit Opposing Roles in Age-Related Blood Pressure Dysregulation.International journal of hypertension · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Background: The inflammatory pathophysiology of hypertension involves interactions between innate and adaptive immune pathways. While interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) have established roles, the contributions of specific T cell-derived cytokines, especially interferon-γ (IFN-γ), interleukin-17A (IL-17A), and interleukin-1 (IL-1), remain less defined in age-stratified human populations. The aging immune system undergoes characteristic shifts that may differentially engage these pathways in regulating blood pressure, with this immune senescence being notably accelerated in people living with HIV (PLWH). Therefore, this study aimed to investigate age-stratified associations between key cytokines and systolic blood pressure (SBP) and to determine how these relationships interact with metabolic factors in both PLWH and non-PLWH. Methods: We conducted a cross-sectional analysis of 332 adults, stratified into two age groups: < 45 years ( Results: The older cohort had significantly higher median SBP, BMI, and LDL cholesterol (all Conclusion: The regulation of blood pressure appears to undergo a fundamental pathophysiological transition with advancing age. In younger adults (< 45 years), SBP is associated with adaptive immune activity, mainly the Th1-associated IFN-γ. After midlife (≥ 45 years), this relationship is superseded by a model dominated by adiposity, within which the Th17-associated IL-17A acts as a contributing inflammatory mediator. These age-stratified cytokine-blood pressure relationships were consistent across PLWH and HIV-negative individuals, suggesting that this pathophysiological succession operates independently of HIV serostatus. Collectively, these findings advocate for age-tailored, mechanism-based approaches to the understanding and managing blood pressure-related risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.